Predictors of diagnosis and survival in idiopathic pulmonary fibrosis and connective tissue disease-related usual interstitial pneumonia

Table 6 Subgroup analysis of clinical predictors of death in IPF

	Univariable HR (95% CI)	P value	Multivariable, HR (95% CI)	P value
Age at biopsy	1.03 (1.02-1.04)	<0.0001	1.03 (1.01-1.04)	0.0002
Gender (male risk)	1.48 (1.15-1.93)	0.003	1.52 (1.15-2.02)	0.003
Smoking Hx	1.13 (0.88-1.46)	0.34	1.04 (0.77-1.37)	0.79
Duration of symptoms prior to biopsy	0.99 (0.99-1.00)	0.51	0.99 (0.99-1.00)	0.40
Autoimmune serology	0.89 (0.65-1.19)	0.43	0.95 (0.69-1.27)	0.72
GERD	1.05 (0.82-1.35)	0.66	1.02 (0.80-1.31)	0.87
FEV_1, % pred	0.98 (0.98-0.99)	0.0004	0.99 (0.97-1.02)	0.53
FVC, % pred	0.98 (0.98-0.99)	0.0001	0.99 (0.98-0.99)	0.03
DLCO, % pred	0.99 (0.98-0.99)	0.0001	0.99 (0.98-0.99)	0.02
TLC, % pred	0.98 (0.98-0.99)	0.0012	1.00 (0.99-1.02)	0.65
Initial HRCT pattern
Probable UIP	0.76 (0.56-1.04)	0.09	0.78 (0.57-1.08)	0.13
Probable NSIP or inconsistent with UIP	0.91 (0.65-1.27)	0.56	0.96 (0.69-1.35)	0.82
Atypical findings on biopsy	0.99 (0.70-1.39)	0.98	0.96 (0.67-1.35)	0.82

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