Table 1 Baseline demographics
Characteristic | Total (N = 625) | IPF (N = 536) | CTD-UIP (N = 89) | P ¶ |
|---|---|---|---|---|
Age at biopsy, Yrs | 63.9 ± 9.9 | 64.7 ± 9.4 | 59.3 ± 11.5 | <0.0001 |
Gender, M/F (%) | 382/243 (61/39) | 345/191 (64/36) | 37/52 (42/58) | <0.0001 |
Smoking history, N (%) | Â | Â | Â | 0.003 |
  Never | 250 (40) | 204 (38) | 46 (52) |  |
  Former | 364 (58) | 325 (60) | 39 (44) |  |
  Current | 11 (2) | 7 (2) | 4 (4) |  |
Reported symptom duration prior to ILD diagnosis, months (range) | 23.9 ± 25.3 (1–180) | 23.6 ± 24.7 (0–180) | 25.3 ± 28.6 (0–120) | 0.56 |
Clinical GERD, N (%) | 362 (58) | 312 (58) | 50 (56) | 0.72 |
Autoimmune serology, N (%) | 180 (39%); N = 460 tested | 111 (29%); N = 378 tested | 69 (78%); N = 82 tested | <0.001 |
FEV1, % pred, mean ± SD | 68 ± 17; N = 552 | 68.4 ± 16.8; N = 475 | 65.7 ± 18.2; N = 77 | 0.21 |
FVC, % pred, mean ± SD | 64.6 ± 17.7; N = 557 | 64.6 ± 17.3; N = 481 | 64 ± 19.7; N = 76 | 0.76 |
TLC, % pred, mean ± SD | 67.2 ± 14.5; N = 478 | 67.2 ± 14.2; N = 412 | 67.7 ± 16.8; N = 66 | 0.77 |
DLCO, % pred, mean ± SD | 47.5 ± 15.6; N = 508 | 47.6 ± 15.7; N = 438 | 47 ± 15.4; N = 70 | 0.74 |
HRCT at Bx, N (%) | N = 584 | N = 502 | N = 82 | 0.09 |
  Consistent with UIP | 136 (23) | 119 (24) | 17 (21) |  |
  Possible UIP | 266 (46) | 235 (47) | 31 (38) |  |
  NSIP or inconsistent UIP | 182 (31) | 148 (29) | 34 (41) |  |
Atypical pathology findings, N (%) | 113 (18) | 83 (15) | 30 (34) | <0.0001 |
Treated, N (%) | 438 (70) | 357 (67) | 81 (91) | <0.0001 |
Lung transplant, N (%) | 33 (5) | 27 (5) | 6 (7) | 0.51 |
Deaths, N (%) | 442 (71) | 391 (73) | 51 (57) | 0.003 |
Median follow-up in months, median (range) | 49.5 (1–223) | 47.7 (1–198) | 79.4 (1–223) | - |