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Table 3 GO Terms associated with relevant genes related to muscle wasting

From: Genome-wide mRNA expression profiling in vastus lateralis of COPD patients with low and normal fat free mass index and healthy controls

Source

GO terms

Fold enrichment

N o of gene in the term

FDR

Up-regulated genes

Traslational initiation

7.9

11

0.001

Traslational elongation

14.7

49

6.05E-42

Ribosomal biogenesis

4.2

17

0.004

rRNA processing

4.9

15

0.002

Muscle organ development

3.2

20

1.62E-05

Striated muscle contraction

6.5

10

1.55E-05

Down-regulated genes

Glucose metabolic process

3.3

21

0.008

Energy derivation by oxidation of organic compounds

5.8

37

4.86E-15

Electron transport chain

6.2

31

5.77E-13

ATP synthesis coupled electron transport

9.3

22

1.91E-12

Striated muscle tissue development

3.4

18

0.02

Muscle contraction

4.7

31

1.94E-09

  1. GO Terms associated with DEGs between COPDL vs. COPDN and COPDL vs. C.
  2. Functional enrichment analysis of 454 up-regulated and 656 down-regulated DEGs between COPDL vs. COPDN and COPDL vs. C (FDR < 0.05) with the corresponding GO term, the fold enrichment, number of genes involved in the term and the FDR (False discovery Rate).
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Respiratory Research

ISSN: 1465-993X

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