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Table 1 Characteristics of the study groups

From: Genome-wide mRNA expression profiling in vastus lateralis of COPD patients with low and normal fat free mass index and healthy controls

  COPD L COPD N Controls p-value
M/F 7/2 A 8/2 A 8/2 A ns
Age (Years) 67 ± 2.0 A 69 ± 1.5 A 68 ± 1.4 A ns
BMI (Kg.m−2) 18.8 ± 0.7 A 26 ± 0.7 B 30 ± 2.1 C <0.0001
FFMI (Kg.m−2) 15 ± 0.2 A 19 ± 0.5 B 20 ± 0.8 B <0.0001
Active/ex-smokers 1/8 A 2/8 A 2/8 A ns
Pack/year 66 ± 14 A 49 ± 6.6 AB 32 ± 5.0 B 0.037
Average cessation (years) 6.0 ± 2.5 A 8.4 ± 2.2 A 23 ± 5.5 B <0.01
Age at smoking cessation (years) 61.1 ± 8.2 A 60.5 ± 7.6 A 45.1 ± 15.5 B <0.01
mMRC 4 ± 0.4 A 3 ± 0.4 B    0.038
FEV1 (L) 0.8 ± 0.1 A 1.2 ± 0.1 A 2.8 ± 0.2 B <0.0001
FEV1 (% pred) 30 ± 3.6 A 44 ± 5.8 A 95 ± 3.9 B <0.0001
FVC (L) 2.6 ± 0.3 A 2.7 ± 0.4 A 3.9 ± 0.2 B 0.015
FVC (% pred) 76 ± 6.4 A 88 ± 9.0 AB 104 ± 3.2 B 0.01
FEV1/FVC 0.32 ± 0.1 A 0.38 ± 0.1 A 0.71 ± 0.0 B <0.0001
PaO2 (mmHg) 79 ± 7.4 A 70 ± 3.1 A 73 ± 1.8 A ns
PaCO2 (mmHg) 43 ± 2.0 A 41 ± 1.1 A 42 ± 0.6 A ns
Physical activity (V) 1.2 ± 0.3 A 7 ± 1.9 B 11 ± 1.5 B <0.0001
Physical activity (L) 43 ± 3.6 A 30 ± 5.0 A    ns
QMVC (N) 213 ± 19.4 A 323 ± 25.6 B 366 ± 26.8 B 0.002
6MWD (m) 306 ± 55 A 411 ± 50.1 AB 524 ± 37.9 B 0.01
BODE 6.5 ± 1.3 A 4 ± 0.9 A    ns
SGRQ Symptoms 76 ± 4.8 A 60 ± 4.2 B    0.01
SGRQ Activity 86 ± 4.7 A 52 ± 9.2 B    0.003
SGRQ Impact 57 ± 6.6 A 33 ± 7.7 B    0.01
SGRQ Total 69 ± 5.4 A 43 ± 6.8 B    0.005
Type I Fibre (%) 25.1 ± 4.6 A 24.4 ± 3.3 A 38.7 ± 3.9 B 0.04
Type II area (μ2) 2033 ± 166 A 2978 ± 277 B 2564 ± 277 AB 0.03
  1. Definition of abbreviations: COPDN = COPD patients with normal FFMI; COPDL = patients with COPD with low FFMI; BMI = Body mass index; FFMI = fat free mass index; MRC = medical research council dyspnoea score; FEV1 = forced expiratory volume in the first second; FVC = forced vital capacity; PaO2 = arterial oxygen partial pressure; PaCO2 = arterial carbon dioxide partial pressure; Physical Activity (V) = Voorrips Questionnaire; Physical activity (L) = London Chest Activity of Daily Living Scale; QMVC = quadriceps maximal voluntary contraction; 6MWD = six minute walking distance; SGRQ = St. George’s Respiratory Questionnaire; ns = not significant; NA = not applicable. Comparisons among groups were done using ANOVA and Student-Newman-Keuls as a post-hoc test. Differences among the three different groups were stated using letters A, B and C where sharing a letter implies no differences between these groups and having a different letter implies a statistical difference in the post-hoc test.