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Table 4 Median (IQR) values of inflammatory markers in induced and spontaneous sputum samples by smoking, GOLD stage and H. influenzae carrier state

From: Comparison of inflammatory markers in induced and spontaneous sputum in a cohort of COPD patients

  Smoking status GOLD stage H. influenzae
  Current smoker n = 15 Ex-smoker n = 29 p* II n = 15 III+IV n = 29 p* No n-12 Yes = n = 12 p*
IL-6(pg/ml)          
induced 17.2(5.7-36.2) 16.7(4.0-43.2) 0.63 16.7(4.5-67.8) 19.4(5.2-36.2) 0.78 20.7(10.9-49.0) 17.8(1.3-28.6) 0.16
spontaneous 10.2(3.0-29.5) 21.5(5.8-48.2) 0.22 15.6(2.2-64.9) 13.8(4.45.8) 0.79 32.2(22.4-75.38) 12.0(2.6-18.8) 0.01
IL-8(pg/ml)          
induced 505.4(161.3-805.9) 517.0(193.3-1257.2) 0.54 233.4(170.0-1257.2) 529.0(224.5-1156.0) 0.37 277.6(170.0-649.0) 655.49(274.70-832.70) 0.32
spontaneous 221.0(165.4-674.4) 405.0(173.2-891.8) 0.42 210.1(112.7-844.1) 546.3(174.7-891.8) 0.18 336.9(210.1-734.2) 570.4(265.8-1141.4) 0.23
IP-10(pg/ml)          
induced 216.5(130.9-826.2) 624.3(289.9-1844.9) 0.08 232.5(175.2-748.3) 600.8(216.7-1844.9) 0.20 477.5(175.2-2554.8) 696.1(56.0-1574.1) 0.85
spontaneous 345.6(124.9-716.5) 461.0(237.5-1361.7) 0.14 354.5(129.7-780.1) 448(237.5-1202.0) 0.33 491.9(285.2-2269.7) 582.7(180.0-1093.0) 0.42
TNF-α(pg/ml)          
induced 0.4(0-1.9) 1.5(0-4.8) 0.34 0.00(0.00-2.5) 1.6(0-4.2) 0.14 2.3(0.0-5.1) 3.2(0.7-24.3) 0.24
spontaneous 0.9(0-3.2) 3.3(0.3-7.4) 0.20 0.5(0.0-4.5) 2.4(0.8-7.4) 0.18 6.43.7-14.0 7.9(2.1-173.9) 0.69
IL-18(pg/ml)          
induced 9.0(0.9-19.3) 8.4(4.1-25.6) 0.58 10.6(2.4-14.9) 6.3(4.1-25.6) 0.91 5.04(0.0-13.6) 4.2(0.6-10.1) 1.0
spontaneous 2.9(0.5-14.8) 14.8(8.3-31.7) 0.01 8.8(1.0-15.1) 14.6(3.5-29.8) 0.24 10.4(5.0-13.9) 7.0(2.7-25.2) 0.45
MIG(pg/ml)          
induced 332.2(30.1-661.7) 806.3(110.5-1391.4) 0.15 121.8(41.2-897.0) 661.7(110.5-1314.3) 0.27 157.8(43.3-1714.8) 677.1(179.0-961.8) 0.54
spontaneous 208.5(31.7-385.8) 626.8(222.6-2031.7) 0.03 280.4(69.8-1537.1) 383.4(205.3-1941.6) 0.47 1473.0 (438.8-4392.9) 740.5(384.6-2088.3) 0.33
  1. *Kruskal-Wallis test.