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Figure 6 | Respiratory Research

Figure 6

From: Epigenetics of hyper-responsiveness to allergen challenge following intrauterine growth retardation rat

Figure 6

Comparison of histone H3 (A), H3K9 (B), and H4 (C) acetylation levels at the ET-1 promoter between IUGR and control rats using ChIP and relative quantitative real-time PCR. A1 and A2 represent two areas of the ET-1 gene promoter (−197 to +25, and −397 to −179, respectively). Data are expressed as IUGR percent of the Control ± SEM. *P <0.05 as compared with Control groups. Note that the levels of acetylated histone H3 and H3K9 in the ET-1 promoter A1 region of lung tissue from IUGR groups were significantly higher than those from the age-matched Control groups; while in the ET-1 promoter A2 region there was no significant statistical difference between IUGR and Control groups. The level of acetylated histone H4 in the ET-1 promoter A1 region of the IUGR OVA group was significantly higher than that of the Control OVA group (n = 4).

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