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Figure 2 | Respiratory Research

Figure 2

From: Epigenetics of hyper-responsiveness to allergen challenge following intrauterine growth retardation rat

Figure 2

Representative immunohistochemical staining for ET-1 (brown) and H&E staining in lung tissues from control 10 weeks (A, E), IUGR 10 weeks (B, F), Control OVA (C, G), and IUGR OVA (D, H) groups (×200). The relative immunostaining densities for ET-1 from OVA-challenged groups were significantly higher than those from non-OVA-exposed groups, especially from IUGR OVA group. There were relatively few eosinophils infiltrations in the Control (E) and IUGR (F) rats. Tissue sections from the OVA-exposed IUGR (H) rats exhibited more predominant eosinophils infiltration compared with the OVA-exposed control rats (G) (×200). The histogram (I) showed the number of infiltrated eosinophil cells in peribronchiolar and perivascular lesions. **P <0.01 as compared with Control 10 weeks and IUGR 10 weeks groups, respectively; ##P = 0.001 as compared with Control OVA group. PA = pulmonary artery; AW = airway (n = 8).

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