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Table 3 Additional clinical characteristics of asthma clusters

From: Defining adult asthma endotypes by clinical features and patterns of volatile organic compounds in exhaled air

Parameter

Cluster 1

Cluster 2

Cluster 3

Cluster 4

Cluster 5

Cluster 6

Cluster 7

n

Age of onset (years)

20.7 ± 16.3

19.5 ± 15.4

19.0 ± 17.9

26.5 ± 20.5

24.1 ± 17.1

28.9 ± 14.8

34.3 ± 16.2

195

Gender (male)

36.4%

52.5%

60.1%

35.7%

37.8%

51.7%

21.4%

195

Age

41.6 ± 15.9

46.4 ± 15.9

56.6 ± 12.1

47.3 ± 14.6

49.5 ± 13.4

54.4 ± 12.4

58.9 ± 16.4

195

BMI

25.0 ± 3.6

25.5 ± 3.1

26.0 ± 4.3

25.9 ± 4.2

25.3 ± 4.7

24.7 ± 3.8

24.7 ± 5.0

195

Tobacco exposure (py)

4.2 ± 6.0

3.3 ± 7.7

6.0 ± 8.0

1.8 ± 4.1

4.2 ± 7.1

5.0 ± 8.6

2.0 ± 3.8

195

Smoker

6.1%

2.5%

7.1%

7.1%

5.4%

3.5%

0%

195

ATS

9.1%

12.5%

35.7%

0%

75.7%

6.9%

78.6%

195

Exhaled NO (ppb)

36 ± 29

32 ± 18

34 ± 30

27 ± 27

43 ± 36

28 ± 18

41 ± 26

195

ECP

27.0 ± 27.0

21.7 ± 13.8

26.2 ± 20.8

11.9 ± 7.2

22.3 ± 16.1

18.9 ± 15.6

31.1 ± 19.8

194

Eosinophils

6.5 ± 4.5

5.6 ± 3.1

6.3 ± 3.6

4.8 ± 5.0

4.8 ± 3.1

4.8 ± 3.8

7.2 ± 4.2

195

IgE

1383 ± 4731

524 ± 883

648 ± 1007

304 ± 340

392 ± 877

80 ± 103

140 ± 262

194

Theophyllin

12.1%

12.5%

32.1%

0%

32.4%

10.3%

57.1%

195

  1. Percentages of male asthma patients, asthma patients who are active smokers, asthma patients fulfilling ATS (American Thoracic Society) criterias for severe asthma and asthma patients with theophylline treatment are shown. In addition, the BMI (body mass index), year of onset, age, exhaled NO (nitric oxide), serum ECP (eosinophilic cationic protein), blood eosinophils, IgE serum levels are shown as mean values ± SD. The units are indicated in the brackets. Lifetime tobacco exposure is indicated in pack years (py).