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Table 2 Values for cluster formation

From: Defining adult asthma endotypes by clinical features and patterns of volatile organic compounds in exhaled air

Parameter

Cluster 1

Cluster 2

Cluster 3

Cluster 4

Cluster 5

Cluster 6

Cluster 7

n

33

40

28

14

37

29

14

Allergies

100%

100%

100%

100%

100%

0%

0%

FEV1

99.7 ± 15.8

96.7 ± 16.3

58.7 ± 14.5

105.0 ± 17.2

73.1 ± 18.0

84.4 ± 18.1

58.3 ± 22.5

FEV1/IVC

0.99 ± 0.09

0.98 ± 0.1

0.77 ± 0.15

1.02 ± 0.05

0.91 ± 0.18

0.92 ± 0.17

0.71 ± 0.21

FEV1 improvement

−4.9 ± 11.8

1.3 ± 7.6

8.6 ± 14.6

−0.4 ± 6.9

2.1 ± 14.0

1.0 ± 11.3

14.8 ± 21.3

Junipere

1.8 ± 1.3

1.6 ± 1.0

3.2 ± 0.8

0.9 ± 0.6

2.8 ± 1.0

1.7 ± 0.9

2.9 ± 1.1

Systemic steroids

0%

0%

0%

7.1%

97.3%

0%

100%

Inhaled steroids

100%

100%

100%

42.9%

100%

96.6%

92.9%

Long β2 mimetics

100%

100%

100%

0%

100%

100%

100%

Short β2 mimetics

0.52 ± 0.94

0.68 ± 1.25

3.93 ± 4.74

0.57 ± 1.40

3.05 ± 3.54

1.10 ± 1.76

3.79 ± 5.32

VOC_141

0.015 ± 0.069

0.191 ± 0.246

0.042 ± 0.119

0.020 ± 0.076

0.163 ± 0.381

0.056 ± 0.165

0.034 ± 0.112

VOC_470

0.033 ± 0.090

0.360 ± 0.253

0.238 ± 0.241

0.126 ± 0.228

0.062 ± 0.143

0.214 ± 0.268

0.174 ± 0.251

VOC_478

0

0.152 ± 0.175

0.041 ± 0.112

0.012 ± 0.046

0.053 ± 0.128

0.104 ± 0.179

0.147 ± 0.195

VOC_424

0.436 ± 0.988

3.228 ± 1.751

1.070 ± 1.654

1.938 ± 1.717

0.933 ± 1.502

1.921 ± 2.031

1.816 ± 1.828

  1. Percentages of patients with allergies, systemic steroids, inhaled steroids and inhaled long acting β2 agonists for asthma treatment are shown. FEV1 (forced expiratory volume in 1 second) values are shown in the percentage of the predicted normal values for FEV1. For the Junipers symptoms score and short β2 agonists the mean values ± SD are indicated. Unit for inhalation of short β2 agonists is puffs per day.