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Figure 4 | Respiratory Research

Figure 4

From: Antenatal exposure of maternal secondhand smoke (SHS) increases fetal lung expression of RAGE and induces RAGE-mediated pulmonary inflammation

Figure 4

A detectable increase in the number of actively apoptosing cells by TUNEL staining was observed in wild type pups exposed to SHS (arrows, B) when compared to room air controls (A). There was no difference in the occurrence of TUNEL-positive cells when room air exposed wild type pups (A) and RAGE KO pups (not shown) were compared. Apoptotic cells were observed in RAGE KO pups exposed to SHS (C, arrow); however, the frequency of positive cells was markedly decreased. Blotting for caspase-3 revealed significantly more active caspase-3 in wild type pups exposed to SHS when compared to RAGE KO pups exposed to SHS (D). Images were at 100X original magnification and scale bars equal 100 nm.

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