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Table 3 Meta-analysis of biomarkers associated with emphysema in COPDGene and TESRA cohorts*

From: The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes

 

COPDGene

TESRA

Adjusted meta-analysis p-value

Variable

Beta coefficient

p-value°

Beta coefficient

p-value°

Percent LAA ≤ -910 HU

RAGE

-1.4

2.6 × 10-5

-0.52

9.2 × 10-7

1.2 × 10 -9

ICAM1

-3.2

9.2 × 10-6

-0.37

3.4 × 10-4

1.5 × 10-7

CCL20#

-0.87

1.3 × 10-4

-0.29

2.2 × 10-3

N/A

Mean lung attenuation at 15 th percentile

RAGE

10.78

1.3 × 10-5

7.08

3.0 × 10-8

2.5 × 10 -10

ICAM1

32.3

1.1 × 10-9

5.14

4.5 × 10-5

6.0 × 10-11

AXL

18.8

1.8 × 10-4

2.53

0.038

3.8 × 10-3

CCL20#

6.44

8.2 × 10-5

4.45

1.3 × 10-4

N/A

  1. *Presented is the regression analysis for each biomarker with an adjusted meta-analysis p value. LAA = low attenuation area; RAGE = Receptor for advanced glycosylation end products; ICAM1 = Intercellular Adhesion Molecule 1; CCL20 = Macrophage Inflammatory Protein-3 alpha; AXL = AXL Receptor Tyrosine Kinase;
  2. °p values for COPDGene and TESRA are two-sided p values.
  3. #CCL20 was a binary variable in COPDGene, therefore it is the presence CCL20 that is negatively associated with emphysema in COPDGene cohort, while CCL20 was a continuous variable in TESRA also associated negatively associated with more severe emphysema. Meta-analysis was not possible given difference in variables (N/A).
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Respiratory Research

ISSN: 1465-993X

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