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Table 2 Biomarkers and covariates associated with radiologic emphysema in the COPDGene cohort (using multiple regression)*

From: The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes

 

%LAA ≤ -950 HU

%LAA ≤ -910 HU

LP15A#

Covariate

Beta coefficient

p-value

Beta coefficient

p-value

Beta coefficient

p-value

FEV1 (% predicted)

-0.07

2.9 × 10-40

-0.05

6.4 × 10-29

0.42

2.1 × 10-47

Body mass index

-0.15

3.2 × 10-10

-0.26

8.2 × 10-22

1.37

3.4 × 10-21

Current active smoking

-1.16

9.1 × 10-5

-0.76

1.3 × 10-7

4.56

7.5 × 10-7

Male gender

0.35

0.002

0.71

7.3 × 10-9

-9.57

0.0001

Age at enrollment

0.04

0.039

0.04

0.006

-0.20

0.039

Biomarker

      

RAGE

-0.69

2.6 × 10-8

-1.10

0.005

10

0.0002

CCL20 (presence)

-0.45

0.0006

-0.35

0.004

2.12

0.009

ICAM1

-0.42

0.001

-2.40

0.007

28.39

3.4 × 10-6

SERPINA7

0.28

0.013

2.11

0.042

-13.69

0.038

CDH13

0.29

0.025

2.62

0.005

-16.91

0.008

CDH1

-0.25

0.039

-2.04

0.006

13.09

0.006

TGFB1 LAP

-0.54

0.0002

    

CCL13

0.35

0.013

    

TNFRSF11B

0.34

0.016

    

CCL8

-0.27

0.023

    

IgA

-0.25

0.03

  

6.09

0.025

SORT1

-0.26

0.038

    

IL2RA

0.27

0.044

    

CCL2

0.25

0.045

    

IL12B (presence)

0.22

0.049

    

MDA LDL (absence)

  

0.33

0.016

-2.07

0.025

FAS

  

1.16

0.016

-8.53

0.014

SFTPD

  

-1.16

0.025

8.34

0.016

AXL

    

17.05

0.002

CXCL10

    

-11.80

0.002

ADIPOQ

    

-7.26

0.015

MB

    

-7.97

0.016

SOD1

    

11.08

0.009

NRCAM

    

-9.26

0.017

  1. *Presented are beta coefficients and p values for multiple regression models of biomarkers and covariates associated with emphysema outcomes. %LAA = Percent low attenuation areas; LP15A = mean lung attenuation at 15th percentile on lung attenuation curve; HU = Hounsfield units; FEV1 = Forced expiratory volume in 1st second; RAGE = Receptor for advanced glycosylation end products; CCL20 = Macrophage Inflammatory Protein-3 alpha; ICAM1 = Intercellular Adhesion Molecule 1; SERPINA7 = Thyroxin-binding globulin; CDH 13 = Cadherin-13; CDH1 = Cadherin-1; TGFB1 LAP = Latency-Associated Peptide of Transforming Growth Factor beta 1; CCL13 = Monocyte Chemotactic Protein 4; TNFRSF11B = Osteoprotegerin; CCL8 = Monocyte Chemotactic Protein 2; IgA = Immunoglobulin A; SORT1 = Sortilin; IL2RA = Interleukin-2 receptor alpha; CCL2 = Monocyte Chemotactic Protein 1; IL-12B = Interleukin-12 Subunit p40; MDA LDL = Malondialdehyde-Modified Low-Density Lipoprotein; FAS = FASLG Receptor; SFTPD = Surfactant protein D; AXL = AXL Receptor Tyrosine Kinase; CXCL10 = Interferon gamma Induced Protein 10; ADIPOQ = Adiponectin; MB = Myoglobin; SOD1 = Superoxide dismutase 1; NRCAM = Neuronal Cell Adhesion Molecule.
  2. #Higher LP15A values indicate less severe emphysema, so positive coefficients are associated with less severe emphysema and negative coefficients are associated with more severe emphysema unlike higher %LAA which is associated with more severe emphysema.
  3. Biomarkers not available for replication in TESRA.
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Respiratory Research

ISSN: 1465-993X

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