Table 1 Demographics of individuals in COPDGene and TESRA studies*

Demographics

Age (years)

61 ± 3

65 ± 0.5

p < 0.01

66.6 ± 0.4

Gender (male/female)

124/123

178/163

p = 0.63

267/121

Current smokers (%)

27

23

p = 0.23

0

Smoking history (pack-years)

38 ± 1

54 ± 2

p < 0.001

48 ± 1

Body mass index (kg/m²)

28.9 ± 2.3

27.8 ± 0.3

p = 0.009

26 ± 0.2

Physiology

FEV₁ post bronchodilator (% predicted)

98 ± 3.6

47 ± 1

p < 0.001

50 ± 0.5

FVC post bronchodilator (% predicted)

96 ± 3.6

79 ± 1

p < 0.001

93 ± 0.9

HRCT measurements

Average % LAA ≤ -950 HU

2.3 ± 1.6

15 ± 0.7

p < 0.001

N/A

% Emphysema <5%

85

31

N/A

% Emphysema 5- <10%

13

15

N/A

% Emphysema 10- <20%

2

25

N/A

% Emphysema ≥ 20%

0

29

N/A

Average % LAA ≤ -910 HU

22.6 ± 3.7

39 ± 0.7

p < 0.001

40.7 ± 0.8

% Emphysema <35%

79

35

% Emphysema 35- <45%

15

19

% Emphysema 45- <55%

5

19

% Emphysema ≥55%

1

27

Average LP15A

-916 ± 4.3

-944 ± 1.3

p < 0.001

-945 ± 1.3

Patient-reported outcomes

MRC dyspnea score

0.5 ± 0.1

2.2 ± 0.1

p < 0.001

2.0 ± 0.03

SGRQ

12 ± 3.9

39 ± 1.1

p < 0.001

46 ± 0.8