Figure 4
SB239063 partly restored the ozone-impaired inhibitory effects of dexamethasone. Twenty-eight asthmatic mice were exposed to 1.0 ppm ozone for 3 hrs. Then equal number of mice (14) received injection of SB239063(4.0 mg/kg, diluted by DMSO) or DMSO only 1 hr before and 4 hr after each O3 exposure. Half number of mice (7) in each group received intraperitoneal injection with dexamethasone (2.0 mg/kg) or saline only 1 hr before each aerosol challenge. Interpretation of A to G is same as Figure 2. *:p < 0.05; **:p < 0.01; ***: p < 0.001; n = 7.