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Table 4 Correlations between E-RS scores and indicators of health status, exercise capacity, and functional performance

From: Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials

  Mpex AZ 1 AZ 2
SGRQ total(N = 233) 6MWT distance(N = 231) SGRQ-C total(N = 745) 6MWT distance(N = 745) FPI-SF total(N = 155) SGRQ-C total(N = 586) ISWT distance(N = 596)
E-RS Scores        
 RS-Total Score 0.65** -0.30*** 0.52** -0.14*** -0.43*** 0.51** -0.18***
 RS-Breathlessness 0.60** -0.33*** 0.54** -0.15*** -0.47*** 0.52** -0.19***
 RS-Cough and Sputum 0.45** -0.14* 0.42** -0.10** -0.28*** 0.41** -0.12**
 RS-Chest Symptoms 0.50** -0.17** 0.40** -0.10** -0.28*** 0.44** -0.15***
  1. Spearman's rank-order correlation; E-RS mean weekly scores (Day -7 to Day -1).
  2. Clinic visit, Day 1, prior to treatment.
  3. Bold coefficients identify constructs with strongest expected relationship.
  4. *p < 0.05; **p < 0.01; ***p < 0.001.
  5. Abbreviations: 6MWT 6-minute walk test, AZ AstraZeneca, E-RS Exacerbations of Chronic Pulmonary Disease Tool - Respiratory Symptoms, FPI-SF Functional Performance Inventory - Short Form, ISWT Incremental Shuttle Walk Test, SGRQ St. George's Respiratory Questionnaire, SGRQ-C St. George's Respiratory Questionnaire for COPD.