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Table 1 Sociodemographic and clinical characteristics

From: Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials

  Mpex AZ 1 AZ 2
(N = 235)* (N = 749) (N = 597)
Age, mean (SD) 63.7 (8.95) 62.3 (8.25) 61.7 (8.27)
Gender, n (% Male) 113 (48.1) 572 (76.4) 443 (74.2)
Race/Ethnicity, n (%)    
 White 214 (91.1) 536 (71.6) 592 (99.2)
 Asian 2 (0.9) 212 (28.3) 0 (0.0)
 Black/African American 18 (7.7) 0 (0.0) 0 (0.0)
 Hispanic or Latino 6 (2.6) 2 (0.3) 2 (0.3)
FEV1, mean (SD)§ 1.2 (0.58) 1.7 (0.49) 1.6 (0.52)
FEV1% predicted, mean (SD) 42.2 (18.10) 58.8 (12.70) 54.2 (15.36)
GOLD stage, n (%)    
 0 22 (9.4) 0 (0.0) 0 (0.0)
 I 2 (0.9) 23 (3.2) 22 (3.8)
 II 55 (23.4) 503 (69.1) 300 (51.9)
 III 89 (37.9) 197 (27.1) 240 (41.5)
 IV 66 (28.1) 5 (0.7) 16 (2.8)
SGRQ total score 57.4 (16.21) 52.6 (18.36) 54.9 (17.14)
Exercise test meters, mean (SD) 289 (121)** 392 (122)** 337 (185)††
RS-Total Score, mean (SD)†† 15.7 (5.93) 15.9 (6.0) 18.2 (5.99)
 RS-Breathlessness 8.2 (5.93) 7.9 (3.17) 8.9 (3.12)
 RS-Cough and Sputum 4.1 (2.08) 4.2 (1.56) 4.7 (1.60)
 RS-Chest Symptoms 3.3 (2.08) 3.8 (1.93) 4.6 (1.91)
  1. *United States.
  2. Australia, Canada, Germany, Japan, Korea, Philippines, Poland, Russia, Slovakia, Taiwan, Ukraine, United States.
  3. Bulgaria, Czech Republic, Hungary, Poland, Romania, Slovakia.
  4. §Post-bronchodilator.
  5. Spirometric classification GOLD 2014 [5].
  6. Range: 0 to 100, higher scores = worse health status; SGRQ-C was used in both AZ studies.
  7. **6 Minute Walk Test (6MWT).
  8. ††Incremental Shuttle Walk Test (ISWT).
  9. ‡‡Baseline, mean (SD) weekly scores, Day -7 to Day 1; Ranges: RS-Total: 0 to 40; RS-Breathlessness: 0 to 17; RS-Cough and Sputum: 0 to 11; RS-Chest Symptoms: 0 to 12; higher scores = more severe symptoms.
  10. Abbreviations: AZ AstraZeneca, FEV 1 forced expiratory volume in 1 second, GOLD Global Initiative for Chronic Obstructive Lung Disease, SD standard deviation, SGRQ St. George's Respiratory Questionnaire, SGRQ-C St. George's Respiratory Questionnaire for COPD.