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Table 1 Sociodemographic and clinical characteristics

From: Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials

 

Mpex

AZ 1

AZ 2

(N = 235)*

(N = 749)†

(N = 597)‡

Age, mean (SD)

63.7 (8.95)

62.3 (8.25)

61.7 (8.27)

Gender, n (% Male)

113 (48.1)

572 (76.4)

443 (74.2)

Race/Ethnicity, n (%)

   

 White

214 (91.1)

536 (71.6)

592 (99.2)

 Asian

2 (0.9)

212 (28.3)

0 (0.0)

 Black/African American

18 (7.7)

0 (0.0)

0 (0.0)

 Hispanic or Latino

6 (2.6)

2 (0.3)

2 (0.3)

FEV1, mean (SD)§

1.2 (0.58)

1.7 (0.49)

1.6 (0.52)

FEV1% predicted, mean (SD)

42.2 (18.10)

58.8 (12.70)

54.2 (15.36)

GOLD¶ stage, n (%)

   

 0

22 (9.4)

0 (0.0)

0 (0.0)

 I

2 (0.9)

23 (3.2)

22 (3.8)

 II

55 (23.4)

503 (69.1)

300 (51.9)

 III

89 (37.9)

197 (27.1)

240 (41.5)

 IV

66 (28.1)

5 (0.7)

16 (2.8)

SGRQ total score∥

57.4 (16.21)

52.6 (18.36)

54.9 (17.14)

Exercise test meters, mean (SD)

289 (121)**

392 (122)**

337 (185)††

RS-Total Score, mean (SD)††

15.7 (5.93)

15.9 (6.0)

18.2 (5.99)

 RS-Breathlessness

8.2 (5.93)

7.9 (3.17)

8.9 (3.12)

 RS-Cough and Sputum

4.1 (2.08)

4.2 (1.56)

4.7 (1.60)

 RS-Chest Symptoms

3.3 (2.08)

3.8 (1.93)

4.6 (1.91)

  1. *United States.
  2. †Australia, Canada, Germany, Japan, Korea, Philippines, Poland, Russia, Slovakia, Taiwan, Ukraine, United States.
  3. ‡Bulgaria, Czech Republic, Hungary, Poland, Romania, Slovakia.
  4. §Post-bronchodilator.
  5. ¶Spirometric classification GOLD 2014 [5].
  6. ∥Range: 0 to 100, higher scores = worse health status; SGRQ-C was used in both AZ studies.
  7. **6 Minute Walk Test (6MWT).
  8. ††Incremental Shuttle Walk Test (ISWT).
  9. ‡‡Baseline, mean (SD) weekly scores, Day -7 to Day 1; Ranges: RS-Total: 0 to 40; RS-Breathlessness: 0 to 17; RS-Cough and Sputum: 0 to 11; RS-Chest Symptoms: 0 to 12; higher scores = more severe symptoms.
  10. Abbreviations: AZ AstraZeneca, FEV 1 forced expiratory volume in 1 second, GOLD Global Initiative for Chronic Obstructive Lung Disease, SD standard deviation, SGRQ St. George's Respiratory Questionnaire, SGRQ-C St. George's Respiratory Questionnaire for COPD.