Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD

Respiratory Research

Table 5 Associations of susceptibility (no/yes) with the change in expression of neutrophil markers after smoking

Dependent variable: change in expression with smoking	Predictor variable: susceptibility y/n^†
n = 47	B	S.E.	p-value
(CD181/CXCR1 (IL-8 receptor)^†	0.130	0.106	0.227
CD54 (ICAM-1)	-1.043	0.878	0.241
A17 (active FcγRII)^†	0.127	0.051	0.016*
A27 (active FcγRII)^†	0.102	0.045	0.028*
CD16^- Eosinophils	0.680	0.695	0.334

Different multiple regression models with susceptibility to COPD (y/n) as predictor value and change in expression of neutrophil markers (CD181/CXCR1, CD54, A17 or A27) or % eosinophils after smoking (T_after-T_before) as dependent variable. B = regression coefficient. *Significant (p < 0.05). ^†all models were adjusted for expression of marker at baseline, age and current smoking n/y. ^‡Data were log-transformed.

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