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Table 4 Inflammatory cells in bronchial biopsies 24 hours after smoking

From: Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD

 

Change with smoking

 

Young non-susceptible

Young susceptible

p-value

 

(n = 25)

(n = 14)

Submucosal

   

CD3+ T-cells

6.8 (-21.9;21.6)

3.2 (-9.1;15.3)

NS

CD4+ T-cells

0.0 (-2.8;11.8)

-0.4 (-7.4;1.5)

NS

CD8+ T-cells

0.2 (-0.8;16.5)

-8.9 (-29.9;11.3)

NS

FOXP3+ T-cells

0.9 (-1.9;2.2)

0.2 (-0.3;1.8)

NS

CD68+ macrophages

2.3 (-1.2;7.2)

-0.4 (-4.0;2.6)

NS

AA1+ mast cells

0.0 (-2.1;11.8)

1.1 (-3.5;2.7)

NS

EPX+ eosinophils

0.8 (0.0;1.0)*

0.0 (-0.7;1.0)

NS

NP57+ neutrophils

1.2 (-5.8;5.2)

1.7 (-6.8;7.4)

NS

% E-selectin pos. vessels

0.0 (-1.0;0.0)

0.0 (-5.2;0.0)

NS

  1. Values are expressed as median change (Tafter-Tbefore) in cell counts with interquartile ranges (IQR), 24 hours after smoking. Inflammatory cells are expressed as cell counts/0.1 mm2. *Significant response to cigarette smoke within the group (Wilcoxon signed-rank tests, p < 0.05). p-values for differences in responses to cigarette smoke between susceptible and non-susceptible subjects (Mann-Whitney U tests, NS = not significant).