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Table 3 Cytokines measured in blood 2 hours after smoking

From: Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD

 

Change with smoking

 

Young non-susceptible

Young susceptible

p-value †

 

(n = 29)

(n = 21)

IL-1β

0.00 (0.00;0.00)

0.00 (0.00;0.00)

NS

IL-6

0.00 (-0.25;0.15)

-0.04 (-1.0;0.06)

NS

IL-8

-0.70 (-1.56;-0.01)*

-0.24 (-1.03;0.68)

NS

GM-CSF

0.00 (-0.20;0.00)*

0.00 (-0.54;0.00)

NS

TNFα

-0.27 (-0.89;0.00)*

-0.35 (-1.11;0.16)*

NS

IFNα

0.00 (-0.84;1.10)

-0.49 (-1.59;1.13)

NS

IL-2

0.00 (-0.46;0.70)

0.00 (-0.70;0.48)

NS

IL-4

0.00 (-0.91;0.00)

0.00 (-0.11;0.00)

NS

IL-5

0.00 (-0.09;0.09)

0.00 (-0.05;0.00)

NS

IL-7

0.79 (0.00;3.97)*

0.00 (-1.07;3.39)

NS

IL-10

0.00 (-1.81;0.00)

0.00 (-1.35;1.46)

NS

IL-12p70

0.00 (-0.31;0.24)

0.00 (-0.83;0.31)

NS

IL-13

0.00 (0.00;1.65)

0.00 (-1.10;1.63)

NS

  1. Values are expressed as median change (Tafter-Tbefore) in cytokine concentration (pg/ml) with interquartile ranges (IQR), two hours after smoking. *Significant response to cigarette smoke within the group (Wilcoxon signed-rank tests, p < 0.05). †p?values for differences in responses to cigarette smoke between susceptible and non-susceptible subjects (Mann-Whitney U tests, NS = not significant).
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Respiratory Research

ISSN: 1465-993X

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