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Table 2 Neutrophil activation markers measured in blood by flow cytometry 2 hours after smoking

From: Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD

 

Change with smoking

 

Young non-susceptible

Young susceptible

p-value

 

(n = 27)

(n = 20)

CD16+ Neutrophils

3.4 (-1.3;6.7)*

1.8 (0.2;4.8)*

NS

CD16- Eosinophils

-3.6 (-5.6;-2.4)*

-2.3 (-3.9;-1.3)*

0.037

CD11b (Mac-1)

-4.6 (-20.3;18.6)

9.9 (-16.4;76.6)

NS

CD32 (FcγRII)

-12.6 (-23.9;2.67)

-12.3 (-31.7;-6.1)*

NS

CD54 (ICAM-1)

-0.8 (-1.6;0.48)

-1.6 (-23.0;-0.13)*

NS (0.072)

CD181/CXCR1 (IL-8 receptor)

-19.2 (-48.2;-2.6)*

-5.2 (-27.9;9.8)

NS (0.073)

CD182/CXCR2 (IL-8 receptor)

-23.5 (-53.0;-6.5)*

-27.7 (-46.5;0.7)*

NS

A17 (active FcγRII)

3.26 (-3.0;3.3)

14.8 (2.6;71.0)*

NS (0.067)

A27 (active FcγRII)

0.4 (-9.6;14.6)

19.0 (0.8;67.8)*

NS (0.078)

  1. Values are expressed as median change (Tafter-Tbefore) in fluorescence intensity (MFI) with interquartile ranges (IQR), two hours after smoking. *Significant response to cigarette smoke within the group (Wilcoxon signed-rank tests, p < 0.05). p-values for differences in responses to cigarette smoke between susceptible and non-susceptible subjects (Mann-Whitney U tests, NS = not significant).