Young (<40 years) | Old (>40 years) | |||
---|---|---|---|---|
Non-susceptible | Susceptible | Healthy controls | COPD | |
(n = 29) | (n = 21) | (n = 27) | (n = 13) | |
Age, years | 21 (20-23) | 31 (22-38)* | 51 (46-62) | 66 (64-70)† |
Gender, male n (%) | 17 (59) | 11 (52) | 23 (85) | 13 (100) |
Pack-years | 1 (0-3) | 5 (2-10)* | 26 (23-36) | 32 (23-46) |
Current smokers, n (%) | 29 (100) | 13 (62)* | 26 (96) | 10 (77) |
Ex-smokers, n (%) | 0 (0) | 0 (0) | 1 (4) | 3 (23) |
Non-smoker, n (%) | 0 (0) | 8 (38) | 0 (0) | 0 (0) |
Cig./day for smoking subjects, n | 3 (1-10) | 8 (2-17) | 14 (8-20) | 6 (3-14)† |
FEV1, %predicted | 106 (101-112) | 110 (104-114) | 106 (102-116) | 65 (60-75)† |
FEV1/FVC, % | 85 (83-91) | 81 (78-87)* | 78 (74-83) | 50 (38-59)† |
RV/TLC, % | 22 (19-24) | 25 (23-28) | 32 (28-37) | 39 (34-48)† |
TLCO/VA, %predicted | 100 (92-110) | 95 (82-105) | 100 (91-106) | 75 (63-96)† |
MEF50, %predicted | 97 (85-119) | 94 (85-108) | 90 (80-151) | 23 (12-29)† |
hsCRP, mg/L | 0.7 (1.6-1.9) | 1.0 (0.6-2.2) | 1.9 (0.6-3.8) | 2.9 (1.0-5.0) |
Blood neutrophils, ×109/L | 3.3 (2.7-3.9) | 3.8 (2.9-4.4) | 3.5 (2.7-4.7) | 3.8 (3.3-5.0) |
Blood eosinophils, ×109/L | 0.16 (0.13-0.26) | 0.12 (0.10-0.19) | 0.17 (0.10-0.20) | 0.20 (0.1-0.4) |