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Table 1 Group characteristics

From: Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD

 

Young (<40 years)

Old (>40 years)

 

Non-susceptible

Susceptible

Healthy controls

COPD

 

(n = 29)

(n = 21)

(n = 27)

(n = 13)

Age, years

21 (20-23)

31 (22-38)*

51 (46-62)

66 (64-70)

Gender, male n (%)

17 (59)

11 (52)

23 (85)

13 (100)

Pack-years

1 (0-3)

5 (2-10)*

26 (23-36)

32 (23-46)

Current smokers, n (%)

29 (100)

13 (62)*

26 (96)

10 (77)

Ex-smokers, n (%)

0 (0)

0 (0)

1 (4)

3 (23)

Non-smoker, n (%)

0 (0)

8 (38)

0 (0)

0 (0)

Cig./day for smoking subjects, n

3 (1-10)

8 (2-17)

14 (8-20)

6 (3-14)

FEV1, %predicted

106 (101-112)

110 (104-114)

106 (102-116)

65 (60-75)

FEV1/FVC, %

85 (83-91)

81 (78-87)*

78 (74-83)

50 (38-59)

RV/TLC, %

22 (19-24)

25 (23-28)

32 (28-37)

39 (34-48)

TLCO/VA, %predicted

100 (92-110)

95 (82-105)

100 (91-106)

75 (63-96)

MEF50, %predicted

97 (85-119)

94 (85-108)

90 (80-151)

23 (12-29)

hsCRP, mg/L

0.7 (1.6-1.9)

1.0 (0.6-2.2)

1.9 (0.6-3.8)

2.9 (1.0-5.0)

Blood neutrophils, ×109/L

3.3 (2.7-3.9)

3.8 (2.9-4.4)

3.5 (2.7-4.7)

3.8 (3.3-5.0)

Blood eosinophils, ×109/L

0.16 (0.13-0.26)

0.12 (0.10-0.19)

0.17 (0.10-0.20)

0.20 (0.1-0.4)

  1. Definition of abbreviations: n number, FEV 1 Forced Expiratory Volume in one second, FVC Forced Vital Capacity, RV Residual Volume, TLC Total Lung Capacity, TLCO/VA transfer coefficient for carbon monoxide, MEF 50 maximal expiratory flow at 50% of vital capacity, hsCRP high-sensitivity C-Reactive Protein.
  2. Data are expressed as medians with interquartile ranges (IQR), unless stated otherwise. *p-value <0.05, young susceptible versus young non-susceptible. p-value <0.05, COPD versus healthy controls.