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Table 4 Semiquantitative analysis of electron microscopy and apoptosis (TUNEL)

From: Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema

  Alveolar-capillary membrane Endothelial cell lesion Pneumocyte II lesion Apoptosis
C 1 (0-1) 0 (0-1) 1 (0.5-1) 0.5 (0-1)
E SAL 4 (3-4)* 4 (3-4)* 3 (3-4)* 3.5 (3-4)*
BM MSC IV 2 (1.5-2.5)*# 2 (2-2.5)*# 2 (1.5-2.5)*# 1 (1-1.75)#
AD MSC 2 (1.5-2)*# 2 (1.5-2.5)*# 2 (2-2.5)*# 1.5 (1-2)#
BM MSC IT 2 (2-2.5)*# 2 (2-2.5)*# 3 (2-3)*# 1 (1-1.75)#
AD MSC 2 (1-2)*# 2 (2-3)*# 2 (2-2.5)*# 1 (-1.75)#
L MSC 2 (2-2.5)*# 3 (2.5-3)*# 2 (2-3)*# 2 (2-2)*#
  1. Values expressed as median (interquartile range) of 4 (E) to 16 (C) animals per group. Pathological findings were graded on a five-point, semiquantitative, severity-based scoring system: 0 = normal lung parenchyma, 1 = changes in 1-25%, 2 = 26-50%, 3 = 51-75%, and 4 = 76-100% of the examined tissue in control (C) and emphysema (E) female C57BL/6 mice treated with saline (SAL) or bone marrow (BM), adipose (AD), or lung (L)-derived mesenchymal stem cells (MSC) intravenously (IV) or intratracheally (IT). *Vs. C group (p < 0.05). #Vs. E-SAL group (p < 0.05).