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Table 3 Lung morphometry and cellularity

From: Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema

   

Normal (%)

Collapse (%)

Hyperinflation (%)

Lm (μm)

Neutrophils (%)

C

91.25 ± 3.91

8.35 ± 3.61

0.40 ± 1.18

35.92 ± 2.55

1.45 ± 0.93

E

SAL

45.34 ± 10.02*

27.73 ± 13.55*

26.93 ± 12.32*

60.08 ± 6.37*

6.28 ± 0.76*

BM-MSC

IV

55.09 ± 11.99*

15.19 ± 3.17*#

29.73 ± 12.20*

41.45 ± 5.37#

1.80 ± 0.70#

AD-MSC

69.33 ± 10.74*#

9.70 ± 4.48#

21.33 ± 9.01*

38.85 ± 4.25#

1.26 ± 0.76#

BM-MSC

IT

69.03 ± 5.18*#

17.21 ± 4.37*

13.77 ± 5.29*#†

38.39 ± 1.20#

1.39 ± 0.10#

AD-MSC

64.01 ± 14.43*#

13.32 ± 4.12#

22.67 ± 13.10*

35.10 ± 0.82#

0.91 ± 0.12#

L-MSC

66.91 ± 8.53*#

7.79 ± 2.84#

25.31 ± 9.57*#

37.27 ± 1.83#

1.46 ± 0.11#

  1. Values expressed as means (±SD) of 7 (E) - 30 (C) animals per group. All values were computed in ten random, non-coincident fields per mice. Fractional area of normal, collapsed, and hyperinflated alveoli. Lm, mean linear intercept. In the control (C) group, saline was instilled intratracheally. In the emphysema (E) groups, mice received porcine pancreatic elastase intratracheally. At day 21, all groups were randomized to receive saline and bone marrow (BM), adipose (AD), or lung (L)-derived mesenchymal stem cells (MSC, 1 × 105 cells) intravenously (IV) or intratracheally (IT). *Vs. C group (p < 0.05). #Vs. E-SAL group (p < 0.05). ‡Vs. BM-MSC-IV group (p < 0.05). ‡Vs. BM-MSC-IT group (p < 0.05).
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Respiratory Research

ISSN: 1465-993X

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