Figure 1

Influenza virus infection causes more severe pulmonary disease in aged mice. A. Body weight change in aged (square) and young (triangular) mice following influenza infection. B. Survival in aged (square) and young (triangular) mice following influenza infection. N=15 for both aged and young mice. C. Infiltration index in aged (solid column) and young (open column) mice following influenza infection. Ten aged and 10 young mice were used for each time-point. D. Cell number in BALF (after lysis of RBC) in aged (solid column) and young (open column) mice following influenza infection. Five aged and 5 young mice were used for each time-point. All error bars represent standard errors. *p<0.05, **p<0.01 by Student t-test. E-H. Representative H&E images of lung sections of young mice before infection (E), and at 12 (F), 15 (G), and 21 (H) dpi. I-L. Representative H&E images of lung sections of aged mice before infection (I), and at 12 (J), 15 (K), and 21 (L) dpi. Scale bar: 500 μm.