Skip to main content

Table 3 Bacterial loads and associated airway inflammation in single and mixed-potentially pathogenic microorganisms (PPMs) colonised samples

From: Inflammatory thresholds and the species-specific effects of colonising bacteria in stable chronic obstructive pulmonary disease

  HI SP MC mixed-PPM p-value†
  n = 21 n = 21 n = 7 n = 15  
Mean (SD) Bacterial load 106.2(1.2) 106.5(1.1) 108.6(1.8) 108.5(1.5) <0.001
Median (IQR) CXCL8 (ng.ml -1 ) 179 90 219 127 0.003
(95-453) (50-194) (140-309) (67-677)  
Median (IQR) IL-1β (ng.ml -1 ) 4.8 0.9 1.4 1.6 <0.001
(0.8-7.8) (0.6-1.5) (0.4-7.2) (0.9-6.7)  
Median (IQR) MPO (μg.ml -1 ) 30.1 27.2 23.6 29.1 0.011
(26.4-38.9) (13.3-37.6) (18.1-35.6) (11.1-51.0)  
  1. Definitions: HI = Haemophilus influenzae; SP = Streptococcus pneumoniae; MC = Moraxella catarrhalis; PPM = potentially pathogenic microorganisms.
  2. p-value refers to One-way ANOVA or Kruskal-Wallis between the single PPMs and mixed-PPM samples.