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Table 1 Clinical characteristics of stable COPD patients, and by colonisation status* at study onset

From: Inflammatory thresholds and the species-specific effects of colonising bacteria in stable chronic obstructive pulmonary disease

 

Overall

Non-colonised

Colonised

p-value†

 

n = 99

n = 64

n = 35

 
 

Mean (SD)

Mean (SD)

Mean (SD)

 

Age (years)

72.1 (8.9)

72.0 (9.3)

72.0 (9.3)

0.947

FEV 1 (L)

1.32 (0.54)

1.36 (0.59)

1.24 (0.44)

0.318

FEV 1 (% predicted)

51.5 (21.6)

53.3 (21.7)

48.1 (21.4)

0.257

FVC (L)

2.80 (0.86)

2.84 (0.93)

2.74 (0.73)

0.607

FEV 1 / FVC ratio (%)

47.2 (13.0)

48.0 (13.4)

45.9 (12.3)

0.440

BMI (kg/m 2 )

26.6 (5.8)

26.9 (5.8)

26.2 (5.8)

0.591

 

Median (IQR)

Median (IQR)

Median (IQR)

 

Exacerbation frequency

2.00 (1.00-3.00)

1.97 (1.04-3.03)

2.04 (1.00-2.89)

0.511

Smoking pack years

48.4 (24.4-67.5)

47.2 (25.4-64.7)

51.0 (25.4-105.6)

0.213

ICS dose (beclomethasone equivalent μg)

1000 (500-2000)

1000 (500-2000)

1000 (500-2000)

0.224

 

N (%)

N (%)

N (%)

 

Male gender

66 (67)

40 (63)

26 (74)

0.234

Current Smokers

34 (34)

23 (36)

11 (31)

0.651

Chronic Bronchitis

78 (79)

49 (77)

29 (83)

0.464

  1. *Bronchial colonisation defined as sputum positive for Haemophilus influenzae (HI), Streptococcus pneumoniae (SP) and/or Moraxella catarrhalis (MC) using quantitative polymerase chain reaction (qPCR).
  2. Definitions: ICS = inhaled corticosteroids; BMI = body mass index.
  3. †p-value refers to unpaired t-test between non-colonised and colonised patients.