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Table 5 Meta-analysis results of COPD with chronic bronchitis (CB) vs . smoking controls and COPD without CB vs . smoking controls for COPD risk alleles previously demonstrated in genome-wide association studies of COPD vs . smoking controls

From: Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease

Locus Gene SNP Risk allele COPD with CBvs. smoking controls COPD without CBvs. smoking controls Permutation testing to assess difference of OR between two meta-analyses, 10,000 times
FRQ OR P FRQ OR P P
4q22 FAM13A rs2869967* C 0.41 1.38 5.61 × 10-10 0.41 1.29 9.73 × 10-10 1.10 × 10-3
4q22 FAM13A rs4416442 C 0.40 1.38 6.87 × 10-10 0.41 1.29 6.97 × 10-10 2.30 × 10-3
4q22 FAM13A rs7671167 T 0.50 1.35 5.58 × 10-9 0.50 1.25 6.63 × 10-8 3.00 × 10-4
4q22 FAM13A rs1964516 T 0.50 1.35 1.04 × 10-8 0.50 1.24 1.12 × 10-7 8.00 × 10-4
4q31 HHIP-AS1 rs13141641 T 0.58 1.27 2.81 × 10-6 0.59 1.25 2.18 × 10-8 1.77 × 10-1
4q31 HHIP-AS1 rs13118928 A 0.58 1.24 2.72 × 10-5 0.59 1.25 3.15 × 10-8 4.54 × 10-1
15q25 CHRNA3 rs12914385 T 0.42 1.27 2.83 × 10-6 0.42 1.22 7.86 × 10-7 5.75 × 10-2
15q25 AGPHD1 rs8034191 C 0.37 1.27 4.29 × 10-6 0.37 1.22 1.34 × 10-6 5.13 × 10-2
15q25 IREB2 rs11858836 A 0.35 1.25 4.10 × 10-5 0.36 1.23 9.27 × 10-7 4.19 × 10-1
19q13 RAB4B rs2604894 G 0.56 1.19 9.89 × 10-4 0.57 1.16 4.70 × 10-4 1.28 × 10-1
14q32 RIN3 rs754388 C 0.81 1.22 3.74 × 10-3 0.82 1.29 2.37 × 10-6 5.84 × 10-2
14q32 RIN3 rs17184313 C 0.82 1.20 6.85 × 10-3 0.83 1.28 4.36 × 10-6 1.92 × 10-2
  1. Definition of abbreviations: FRQ risk allele frequency; OR odds ratio; SNP single nucleotide polymorphism.
  2. *Cho MH, et al. Variants in FAM13A Are Associated With Chronic Obstructive Pulmonary Disease. Nat Genet 2010;42:200-202.
  3. Cho MH, et al. unpublished data.
  4. Cho MH, et al. A Genome-Wide Association Study of COPD Identifies a Susceptibility Locus on Chromosome 19q13. Hum Mol Genet 2012;21:947-957.
  5. Pillai SG, et al. A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci. PLoS Genet 2009;5:e1000421.