Table 5 Meta-analysis results of COPD with chronic bronchitis (CB) vs . smoking controls and COPD without CB vs . smoking controls for COPD risk alleles previously demonstrated in genome-wide association studies of COPD vs . smoking controls
From: Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease
Locus | Gene | SNP | Risk allele | COPD with CBvs. smoking controls | COPD without CBvs. smoking controls | Permutation testing to assess difference of OR between two meta-analyses, 10,000 times | ||||
|---|---|---|---|---|---|---|---|---|---|---|
FRQ | OR | P | FRQ | OR | P | P | ||||
4q22 | FAM13A | rs2869967* | C | 0.41 | 1.38 | 5.61 × 10-10 | 0.41 | 1.29 | 9.73 × 10-10 | 1.10 × 10-3 |
4q22 | FAM13A | rs4416442†| C | 0.40 | 1.38 | 6.87 × 10-10 | 0.41 | 1.29 | 6.97 × 10-10 | 2.30 × 10-3 |
4q22 | FAM13A | rs7671167†| T | 0.50 | 1.35 | 5.58 × 10-9 | 0.50 | 1.25 | 6.63 × 10-8 | 3.00 × 10-4 |
4q22 | FAM13A | rs1964516†| T | 0.50 | 1.35 | 1.04 × 10-8 | 0.50 | 1.24 | 1.12 × 10-7 | 8.00 × 10-4 |
4q31 | HHIP-AS1 | rs13141641†| T | 0.58 | 1.27 | 2.81 × 10-6 | 0.59 | 1.25 | 2.18 × 10-8 | 1.77 × 10-1 |
4q31 | HHIP-AS1 | rs13118928†| A | 0.58 | 1.24 | 2.72 × 10-5 | 0.59 | 1.25 | 3.15 × 10-8 | 4.54 × 10-1 |
15q25 | CHRNA3 | rs12914385†| T | 0.42 | 1.27 | 2.83 × 10-6 | 0.42 | 1.22 | 7.86 × 10-7 | 5.75 × 10-2 |
15q25 | AGPHD1 | rs8034191†| C | 0.37 | 1.27 | 4.29 × 10-6 | 0.37 | 1.22 | 1.34 × 10-6 | 5.13 × 10-2 |
15q25 | IREB2 | rs11858836†| A | 0.35 | 1.25 | 4.10 × 10-5 | 0.36 | 1.23 | 9.27 × 10-7 | 4.19 × 10-1 |
19q13 | RAB4B | rs2604894†| G | 0.56 | 1.19 | 9.89 × 10-4 | 0.57 | 1.16 | 4.70 × 10-4 | 1.28 × 10-1 |
14q32 | RIN3 | rs754388†| C | 0.81 | 1.22 | 3.74 × 10-3 | 0.82 | 1.29 | 2.37 × 10-6 | 5.84 × 10-2 |
14q32 | RIN3 | rs17184313†| C | 0.82 | 1.20 | 6.85 × 10-3 | 0.83 | 1.28 | 4.36 × 10-6 | 1.92 × 10-2 |