Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 4 Top results of the meta-analysis for chronic bronchitis (CB) versus no CB within COPD subjects of COPDGene non-Hispanic white, GenKOLS, and ECLIPSE studies *

From: Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease

Locus Nearest gene SNP Risk allele FRQ COPDGene NHWs GenKOLS ECLIPSE Overall
OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P I 2 Q
1q23 RPL31P11 rs114931935 A 0.04 1.98 (1.42-2.78) 6.43 × 10-5 2.11 (1.07-4.15) 3.10 × 10-2 1.64 (1.07-2.51) 2.21 × 10-2 1.88 (1.47-2.40) 4.99 × 10-7 0 0.74
1q23 RPL31P11 rs114384494 T 0.04 2.01 (1.43-2.84) 7.04 × 10-5 2.18 (1.08-4.38) 2.92 × 10-2 1.61 (1.03-2.51) 3.62 × 10-2 1.89 (1.47-2.44) 8.86 × 10-7 0 0.67
1q23 ATF6 rs924777 G 0.12 1.23 (1.03-1.46) 2.20 × 10-2 1.21 (0.89-1.64) 2.19 × 10-1 1.69 (1.36-2.10) 2.30 × 10-6 1.36 (1.20-1.54) 1.33 × 10-6 65 0.06
1q23 ATF6 rs2298019 A 0.12 1.23 (1.03-1.47) 1.98 × 10-2 1.25 (0.93-1.70) 1.43 × 10-1 1.66 (1.33-2.06) 6.41 × 10-6 1.36 (1.20-1.54) 1.36 × 10-6 56 0.10
  1. Definition of abbreviations: CI confidence interval, FRQ risk allele frequency, NHW non-Hispanic white, OR odds ratio, SNP single nucleotide polymorphism.
  2. *Adjusted for age, sex, pack-years of cigarette smoking and genetic ancestry as summarized in the principal components.
  3. Imputed genotypes.