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Table 4 Top results of the meta-analysis for chronic bronchitis (CB) versus no CB within COPD subjects of COPDGene non-Hispanic white, GenKOLS, and ECLIPSE studies *

From: Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease

Locus

Nearest gene

SNP

Risk allele

FRQ

COPDGene NHWs

GenKOLS

ECLIPSE

Overall

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

I 2

Q

1q23

RPL31P11

rs114931935

A

0.04

1.98† (1.42-2.78)

6.43 × 10-5

2.11† (1.07-4.15)

3.10 × 10-2

1.64† (1.07-2.51)

2.21 × 10-2

1.88 (1.47-2.40)

4.99 × 10-7

0

0.74

1q23

RPL31P11

rs114384494

T

0.04

2.01† (1.43-2.84)

7.04 × 10-5

2.18† (1.08-4.38)

2.92 × 10-2

1.61† (1.03-2.51)

3.62 × 10-2

1.89 (1.47-2.44)

8.86 × 10-7

0

0.67

1q23

ATF6

rs924777

G

0.12

1.23† (1.03-1.46)

2.20 × 10-2

1.21 (0.89-1.64)

2.19 × 10-1

1.69 (1.36-2.10)

2.30 × 10-6

1.36 (1.20-1.54)

1.33 × 10-6

65

0.06

1q23

ATF6

rs2298019

A

0.12

1.23† (1.03-1.47)

1.98 × 10-2

1.25† (0.93-1.70)

1.43 × 10-1

1.66† (1.33-2.06)

6.41 × 10-6

1.36 (1.20-1.54)

1.36 × 10-6

56

0.10

  1. Definition of abbreviations: CI confidence interval, FRQ risk allele frequency, NHW non-Hispanic white, OR odds ratio, SNP single nucleotide polymorphism.
  2. *Adjusted for age, sex, pack-years of cigarette smoking and genetic ancestry as summarized in the principal components.
  3. †Imputed genotypes.