From: Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease
Locus | Nearest gene | SNP | Risk allele | FRQ | COPDGene NHWs | GenKOLS | ECLIPSE | Overall | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | I 2 | Q | |||||
1q23 | RPL31P11 | rs114931935 | A | 0.04 | 1.98†(1.42-2.78) | 6.43 × 10-5 | 2.11†(1.07-4.15) | 3.10 × 10-2 | 1.64†(1.07-2.51) | 2.21 × 10-2 | 1.88 (1.47-2.40) | 4.99 × 10-7 | 0 | 0.74 |
1q23 | RPL31P11 | rs114384494 | T | 0.04 | 2.01†(1.43-2.84) | 7.04 × 10-5 | 2.18†(1.08-4.38) | 2.92 × 10-2 | 1.61†(1.03-2.51) | 3.62 × 10-2 | 1.89 (1.47-2.44) | 8.86 × 10-7 | 0 | 0.67 |
1q23 | ATF6 | rs924777 | G | 0.12 | 1.23†(1.03-1.46) | 2.20 × 10-2 | 1.21 (0.89-1.64) | 2.19 × 10-1 | 1.69 (1.36-2.10) | 2.30 × 10-6 | 1.36 (1.20-1.54) | 1.33 × 10-6 | 65 | 0.06 |
1q23 | ATF6 | rs2298019 | A | 0.12 | 1.23†(1.03-1.47) | 1.98 × 10-2 | 1.25†(0.93-1.70) | 1.43 × 10-1 | 1.66†(1.33-2.06) | 6.41 × 10-6 | 1.36 (1.20-1.54) | 1.36 × 10-6 | 56 | 0.10 |