From: Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease
Locus | Nearest gene | SNP | Risk allele | FRQ | COPDGene NHWs | GenKOLS | ECLIPSE | Overall | Â | Â | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P | OR (95% CI) | P | OR (95 CI) | P | OR (95% CI) | P | I 2 | Q | |||||
4q22 | FAM13A | rs2869967 | C | 0.41 | 1.33 (1.17-1.51) | 9.92 × 10-6 | 1.56 (1.25-1.95) | 8.08 × 10-5 | 1.40 (1.04-1.88) | 2.66x10-2 | 1.38 (1.25-1.53) | 5.61 × 10-10 | 0 | 0.46 |
4q22 | FAM13A | rs2045517 | T | 0.40 | 1.33†(1.17-1.51) | 9.87 × 10-6 | 1.56†(1.25-1.95) | 7.88 × 10-5 | 1.40†(1.04-1.88) | 2.67 × 10-2 | 1.38 (1.25-1.53) | 5.63 × 10-10 | 0 | 0.46 |
4q22 | FAM13A | rs7671167 | T | 0.51 | 1.32 (1.16-1.49) | 1.69 × 10-5 | 1.44 (1.15-1.80) | 1.27 × 10-3 | 1.41 (1.06-1.87) | 1.73 × 10-2 | 1.35 (1.22-1.50) | 5.58 × 10-9 | 0 | 0.75 |
4q22 | FAM13A | rs2904259 | C | 0.50 | 1.31†(1.16-1.49) | 1.85 × 10-5 | 1.44†(1.15-1.80) | 1.33 × 10-3 | 1.41†(1.06-1.87) | 1.73 × 10-2 | 1.35 (1.22-1.49) | 6.25 × 10-9 | 0 | 0.75 |
11p15 | EFCAB4A | rs34391416 | A | 0.05 | 2.38 (1.81-3.13) | 6.11 × 10-10 | 1.21†(0.68-2.16) | 5.18 × 10-1 | 0.80†(0.35-1.79) | 5.79 × 10-1 | 1.93 (1.53-2.45) | 4.99 × 10-8 | 79 | 0.01 |
11p15 | CHID1 | rs147862429 | T | 0.05 | 2.77†(2.02-3.81) | 2.90 × 10-10 | 1.34†(0.71-2.53) | 3.68 × 10-1 | 0.58†(0.24-1.39) | 2.23 × 10-1 | 2.09 (1.60-2.74) | 7.87 × 10-8 | 85 | 0.001 |
2q14 | PCDP1 | rs139257032 | T | 0.02 | 2.78†(1.57-4.92) | 4.60 × 10-4 | 4.17†(1.82-9.57) | 7.41 × 10-4 | 10.79†(1.27-91.39 | 2.91 × 10-2 | 3.35 (2.12-5.30) | 2.53 × 10-7 | 0 | 0.4 |
15q26 | MCTP2 | rs12910412 | G | 0.46 | 1.29†(1.14-1.46) | 4.37 × 10-5 | 1.30†(1.03-1.64) | 2.49 × 10-2 | 1.33†(0.98-1.78) | 6.37 × 10-2 | 1.30 (1.17-1.44) | 5.22 × 10-7 | 0 | 0.99 |
11p15 | CHID1 | rs139090846 | T | 0.01 | 4.65†(2.77-7.80) | 5.67 × 10-9 | 1.13†(0.33-3.89) | 8.41 × 10-1 | 0.75†(0.19-2.91) | 6.78 × 10-1 | 3.15 (2.01-4.94) | 5.62 × 10-7 | 78 | 0.01 |
11p15 | AP2A2 | rs143705409 | G | 0.05 | 2.62†(1.93-3.56) | 7.19 × 10-10 | 1.32†(0.73-2.40) | 3.61 × 10-1 | 0.52†(0.24-1.11) | 8.95 × 10-2 | 1.92 (1.49-2.49) | 6.16 × 10-7 | 88 | 0.0002 |
11p15 | AP2A2 | rs185786041 | C | 0.05 | 2.61†(1.92-3.54) | 8.44 × 10-10 | 1.31†(0.73-2.35) | 4.26 × 10-1 | 0.54†(0.26-1.11) | 9.50 × 10-2 | 1.89 (1.47-2.44) | 9.20 × 10-7 | 88 | 0.0002 |
11p15 | AP2A2 | rs117455145 | G | 0.05 | 2.61†(1.92-3.54) | 8.50 × 10-10 | 1.31†(0.73-2.34) | 4.27 × 10-1 | 0.54†(0.26-1.11) | 9.28 × 10-2 | 1.89 (1.46-2.43) | 9.68 × 10-7 | 88 | 0.0002 |