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Table 2 Top results of the meta-analysis for COPD subjects with chronic bronchitis versus smokers with normal spirometry in COPDGene non-Hispanic white, GenKOLS, and ECLIPSE studies *

From: Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease

Locus

Nearest gene

SNP

Risk allele

FRQ

COPDGene NHWs

GenKOLS

ECLIPSE

Overall

  

OR (95% CI)

P

OR (95% CI)

P

OR (95 CI)

P

OR (95% CI)

P

I 2

Q

4q22

FAM13A

rs2869967

C

0.41

1.33 (1.17-1.51)

9.92 × 10-6

1.56 (1.25-1.95)

8.08 × 10-5

1.40 (1.04-1.88)

2.66x10-2

1.38 (1.25-1.53)

5.61 × 10-10

0

0.46

4q22

FAM13A

rs2045517

T

0.40

1.33† (1.17-1.51)

9.87 × 10-6

1.56† (1.25-1.95)

7.88 × 10-5

1.40† (1.04-1.88)

2.67 × 10-2

1.38 (1.25-1.53)

5.63 × 10-10

0

0.46

4q22

FAM13A

rs7671167

T

0.51

1.32 (1.16-1.49)

1.69 × 10-5

1.44 (1.15-1.80)

1.27 × 10-3

1.41 (1.06-1.87)

1.73 × 10-2

1.35 (1.22-1.50)

5.58 × 10-9

0

0.75

4q22

FAM13A

rs2904259

C

0.50

1.31† (1.16-1.49)

1.85 × 10-5

1.44† (1.15-1.80)

1.33 × 10-3

1.41† (1.06-1.87)

1.73 × 10-2

1.35 (1.22-1.49)

6.25 × 10-9

0

0.75

11p15

EFCAB4A

rs34391416

A

0.05

2.38 (1.81-3.13)

6.11 × 10-10

1.21† (0.68-2.16)

5.18 × 10-1

0.80† (0.35-1.79)

5.79 × 10-1

1.93 (1.53-2.45)

4.99 × 10-8

79

0.01

11p15

CHID1

rs147862429

T

0.05

2.77† (2.02-3.81)

2.90 × 10-10

1.34† (0.71-2.53)

3.68 × 10-1

0.58† (0.24-1.39)

2.23 × 10-1

2.09 (1.60-2.74)

7.87 × 10-8

85

0.001

2q14

PCDP1

rs139257032

T

0.02

2.78† (1.57-4.92)

4.60 × 10-4

4.17† (1.82-9.57)

7.41 × 10-4

10.79† (1.27-91.39

2.91 × 10-2

3.35 (2.12-5.30)

2.53 × 10-7

0

0.4

15q26

MCTP2

rs12910412

G

0.46

1.29† (1.14-1.46)

4.37 × 10-5

1.30† (1.03-1.64)

2.49 × 10-2

1.33† (0.98-1.78)

6.37 × 10-2

1.30 (1.17-1.44)

5.22 × 10-7

0

0.99

11p15

CHID1

rs139090846

T

0.01

4.65† (2.77-7.80)

5.67 × 10-9

1.13† (0.33-3.89)

8.41 × 10-1

0.75† (0.19-2.91)

6.78 × 10-1

3.15 (2.01-4.94)

5.62 × 10-7

78

0.01

11p15

AP2A2

rs143705409

G

0.05

2.62† (1.93-3.56)

7.19 × 10-10

1.32† (0.73-2.40)

3.61 × 10-1

0.52† (0.24-1.11)

8.95 × 10-2

1.92 (1.49-2.49)

6.16 × 10-7

88

0.0002

11p15

AP2A2

rs185786041

C

0.05

2.61† (1.92-3.54)

8.44 × 10-10

1.31† (0.73-2.35)

4.26 × 10-1

0.54† (0.26-1.11)

9.50 × 10-2

1.89 (1.47-2.44)

9.20 × 10-7

88

0.0002

11p15

AP2A2

rs117455145

G

0.05

2.61† (1.92-3.54)

8.50 × 10-10

1.31† (0.73-2.34)

4.27 × 10-1

0.54† (0.26-1.11)

9.28 × 10-2

1.89 (1.46-2.43)

9.68 × 10-7

88

0.0002

  1. Definition of abbreviations: CI confidence interval, FRQ risk allele frequency, NHW non-Hispanic white, OR odds ratio, SNP single nucleotide polymorphism.
  2. *Adjusted for age, sex, pack-years of cigarette smoking and genetic ancestry as summarized in the principal components.
  3. †Imputed genotypes.