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Table 2 Top results of the meta-analysis for COPD subjects with chronic bronchitis versus smokers with normal spirometry in COPDGene non-Hispanic white, GenKOLS, and ECLIPSE studies *

From: Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease

Locus Nearest gene SNP Risk allele FRQ COPDGene NHWs GenKOLS ECLIPSE Overall   
OR (95% CI) P OR (95% CI) P OR (95 CI) P OR (95% CI) P I 2 Q
4q22 FAM13A rs2869967 C 0.41 1.33 (1.17-1.51) 9.92 × 10-6 1.56 (1.25-1.95) 8.08 × 10-5 1.40 (1.04-1.88) 2.66x10-2 1.38 (1.25-1.53) 5.61 × 10-10 0 0.46
4q22 FAM13A rs2045517 T 0.40 1.33 (1.17-1.51) 9.87 × 10-6 1.56 (1.25-1.95) 7.88 × 10-5 1.40 (1.04-1.88) 2.67 × 10-2 1.38 (1.25-1.53) 5.63 × 10-10 0 0.46
4q22 FAM13A rs7671167 T 0.51 1.32 (1.16-1.49) 1.69 × 10-5 1.44 (1.15-1.80) 1.27 × 10-3 1.41 (1.06-1.87) 1.73 × 10-2 1.35 (1.22-1.50) 5.58 × 10-9 0 0.75
4q22 FAM13A rs2904259 C 0.50 1.31 (1.16-1.49) 1.85 × 10-5 1.44 (1.15-1.80) 1.33 × 10-3 1.41 (1.06-1.87) 1.73 × 10-2 1.35 (1.22-1.49) 6.25 × 10-9 0 0.75
11p15 EFCAB4A rs34391416 A 0.05 2.38 (1.81-3.13) 6.11 × 10-10 1.21 (0.68-2.16) 5.18 × 10-1 0.80 (0.35-1.79) 5.79 × 10-1 1.93 (1.53-2.45) 4.99 × 10-8 79 0.01
11p15 CHID1 rs147862429 T 0.05 2.77 (2.02-3.81) 2.90 × 10-10 1.34 (0.71-2.53) 3.68 × 10-1 0.58 (0.24-1.39) 2.23 × 10-1 2.09 (1.60-2.74) 7.87 × 10-8 85 0.001
2q14 PCDP1 rs139257032 T 0.02 2.78 (1.57-4.92) 4.60 × 10-4 4.17 (1.82-9.57) 7.41 × 10-4 10.79 (1.27-91.39 2.91 × 10-2 3.35 (2.12-5.30) 2.53 × 10-7 0 0.4
15q26 MCTP2 rs12910412 G 0.46 1.29 (1.14-1.46) 4.37 × 10-5 1.30 (1.03-1.64) 2.49 × 10-2 1.33 (0.98-1.78) 6.37 × 10-2 1.30 (1.17-1.44) 5.22 × 10-7 0 0.99
11p15 CHID1 rs139090846 T 0.01 4.65 (2.77-7.80) 5.67 × 10-9 1.13 (0.33-3.89) 8.41 × 10-1 0.75 (0.19-2.91) 6.78 × 10-1 3.15 (2.01-4.94) 5.62 × 10-7 78 0.01
11p15 AP2A2 rs143705409 G 0.05 2.62 (1.93-3.56) 7.19 × 10-10 1.32 (0.73-2.40) 3.61 × 10-1 0.52 (0.24-1.11) 8.95 × 10-2 1.92 (1.49-2.49) 6.16 × 10-7 88 0.0002
11p15 AP2A2 rs185786041 C 0.05 2.61 (1.92-3.54) 8.44 × 10-10 1.31 (0.73-2.35) 4.26 × 10-1 0.54 (0.26-1.11) 9.50 × 10-2 1.89 (1.47-2.44) 9.20 × 10-7 88 0.0002
11p15 AP2A2 rs117455145 G 0.05 2.61 (1.92-3.54) 8.50 × 10-10 1.31 (0.73-2.34) 4.27 × 10-1 0.54 (0.26-1.11) 9.28 × 10-2 1.89 (1.46-2.43) 9.68 × 10-7 88 0.0002
  1. Definition of abbreviations: CI confidence interval, FRQ risk allele frequency, NHW non-Hispanic white, OR odds ratio, SNP single nucleotide polymorphism.
  2. *Adjusted for age, sex, pack-years of cigarette smoking and genetic ancestry as summarized in the principal components.
  3. Imputed genotypes.