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Table 1 Effect of neonatal hyperoxia exposure on lung function

From: The effect of CSF-1 administration on lung maturation in a mouse model of neonatal hyperoxia exposure

  Normoxia Hyperoxia Significance p value
Tidal volume (μL) 13.64 ± 0.76 10.74 ± 0.34 *** 0.0008
Minute volume (ml/min) 3.28 ± 0.25 2.34 ± 0.13 ** 0.0014
Frequency (breaths/min) 238.0 + 6.63 216.4 ± 6.18 * 0.031
Total cycle time (ms) 254.2 ± 7.32 276.9 ± 7.07 * 0.044
Inspiration time (ms) 72.51 ± 3.85 82.75 ± 3.64   0.076
Expiration time (ms) 137.7 ± 22.11 206.4 ± 10.76 ** 0.005
Inspiratory flow rate (μL/sec) 191.6 ± 12.93 133.5 ± 8.06 *** 0.0006
Inspiratory duty cycle (%) 28.73 ± 1.66 29.99 ± 1.29   0.55
Tidal volume (μL)/bw (g) 3.11 ± 0.11 2.98 ± 0.17   0.56
Minute volume (ml/min)/bw (g) 744.0 ± 42.11 650.8 ± 48.17   0.19
  1. *p < 0.05, **p < 0.01, ***p <0.001.
  2. Plethysmographic analysis of respiratory parameters in neonates exposed to normoxia or hyperoxia for 7 days following birth. Hyperoxia exposure resulted in significant perturbation of lung function at P7, compared to normoxia controls, n = 9/16 per group. Data were analysed using two-tailed unpaired t-tests. Bw – body weight.