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Figure 1 | Respiratory Research

Figure 1

From: Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis

Figure 1

A 78-year-old male with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). High resolution computed tomography (HRCT) images at the initial diagnosis of IPF showed subpleural-predominant interstitial fibrosis, traction bronchiectasis (arrow) and honeycombing (arrowhead) (A). HRCT images at the onset of acute exacerbation (12 months after the initial diagnosis) showed diffuse areas of ground glass attenuations superimposed on underlying fibrotic opacities (B). The underling fibrotic lesions were classified as the UIP pattern, including dense interstitial fibrosis with focal squamous or bronchial metaplasia (inset), alternating with only bland-looking alveolar walls (H&E, ×100) (C). DAD with hyaline membranes (inset) superimposed on a background fibrotic and edematous lung with several fibroblastic foci (H&E, ×100) (D).

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