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Table 4 Inflammatory mediators in serum/blood

From: Compartment differences of inflammatory activity in chronic obstructive pulmonary disease

  

Healthy non-smoker

Smokers without COPD

Smokers with COPD

 

Serum

MMP-9 (ng/ml)

430 (251-577)

490 (382-801)

757** (557-1000)

P = 0.006

 

TIMP-1 (ng/ml)

282 (221-367)

358 (266-442)

338 (298-544)

P = 0.104

 

MMP-9/TIMP-1

1.21 (0.92-1.93)

1.31 (0.96-2.29)

2.13 (1.57-2.81)

P = 0.116

 

CRP (mg/l)

0.75 (0.40-1.20)

1.80** (1.00-2.70)

2.45** (0.73-4.30)

P = 0.004

 

TNF-α (pg/ml)

1.39 (0.72-1.93)

1.22 (1.08-1.53)

0.64*# (<0.5-1.30)

P = 0.049

 

sTNFR1 (pg/ml)

1353 (817-1570)

1322 (1166-1855)

1302 (943-1829)

P = 0.848

 

sTNFR2 (pg/ml)

3499 (2806-3708)

3561 (3097-3919)

3750 (2975-4261)

P = 0.826

Blood

TNFR1 on monocytes (rMFI)

11.8 (10.5-15.0)

12.5 (9.9-13.7)

13.2 (11.3-15.7)

P = 0.600

 

TNFR2 on monocytes (rMFI)

28.2 (21.3-47.8)

31.1 (25.0-40.9)

44.0 (28.9-52.2)

P = 0.342

 

TNFR1 on neutrophils (rMFI)

6.95 (6.24-9.45)

6.74 (5.42-7.70)

6.69 (5.70-7.92)

P = 0.509

 

TNFR2 on neutrophils (rMFI)

11.8 (8.79-14.6)

8.28 (7.30-9.97)

7.82 (6.58-10.6)

P = 0.117

  1. Results are presented as median and 25th-75th percentiles.
  2. P-values indicate comparisons between groups (Kruskal-Wallis test), bold data indicate significance.
  3. IL-6 and IL-8 were below detection limit (<3 pg/ml, <12.5 pg/ml) in serum in almost all subjects.
  4. *, **indicate P < 0.05 and P < 0.01, respectively, compared with healthy non-smokers (Mann-Whitney U-test).
  5. # indicate P < 0.05 compared with smokers without COPD (Mann-Whitney U-test).
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Respiratory Research

ISSN: 1465-993X

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