From: Compartment differences of inflammatory activity in chronic obstructive pulmonary disease
Healthy non-smoker | Smokers without COPD | Smokers with COPD | P-value | ||
---|---|---|---|---|---|
Sputum | IL-6 (pg/ml) | 33.4 (11.5-62.6) | 223*** (78.9-641) | 486*** (262-1031) | P < 0.001 |
IL-8 (pg/ml) | 628 (430-1351) | 1100 (595-1710) | 2941**# (980-4912) | P = 0.010 | |
MMP-9 (ng/ml) | 21.6 (13.3-109) | 57.3 (30.2-106) | 97.5 (17.4-408) | P = 0.091 | |
TIMP-1 (ng/ml) | 117.5 (28.7-257) | 96.6 (46.4-242) | 166 (69.4-346) | P = 0.423 | |
MMP-9/TIMP-1 | 0.35 (0.14-1.36) | 0.78 (0.19-1.72) | 0.70 (0.22-1.80) | P = 0.636 | |
TNF-α (pg/ml) | 1.17 (<1.00-4.88) | <1.00 (<1.00) | <1.00 (<1.00-8.05) | P = 0.123 | |
sTNFR1 (pg/ml) | 589 (59-996) | 205 (36-536) | 80 (16-560) | P = 0.207 | |
sTNFR2 (pg/ml) | 140 (65-469) | 196 (118-344) | 204 (43-545) | P = 0.996 | |
TNFR1 on neutrophils (rMFI) | 1.94 (1.46-2.48) | 2.70 (2.36-2.94) | 1.76 (1.44-2.12) | P = 0.076 | |
TNFR2 on neutrophils (rMFI) | 1.58 (1.37-1.67) | 1.63 (1.35-1.93) | 1.34 (1.17-1.49) | P = 0.236 | |
BAL | IL-8 (pg/ml) | <12.5 (<12.5-15.8) | <12.5 (<12.5-33.0) | 20.3 (<12.5-31.8) | P = 0.459 |
MMP-9 (ng/ml) | 0.69 (0.44-1.45) | 0.97 (0.58-1.27) | 1.38 (0.93-3.87) | P = 0.112 | |
TIMP-1 (ng/ml) | 1.85 (1.46-3.71) | 3.92** (2.71-9.34) | 3.46** (2.18-7.85) | P = 0.010 | |
MMP-9/TIMP-1 | 0.51 (0.18-0.77) | 0.25 (0.11-0.62) | 0.42 (0.11-0.74) | P = 0.654 | |
sTNFR1 (pg/ml) | 82.2 (75.4-118) | 161** (102-203) | 92.9 # (73.7-133) | P = 0.009 | |
sTNFR2 (pg/ml) | 36.0 (24.8-50.2) | 77.7** (54.6-110) | 69.5* (34.6-88.5) | P = 0.003 | |
Macrophages TNF-α (2 -∆Ct) | 0.05 (0.04-0.12) | 0.02* (0.02-0.03) | 0.01* (0.01-0.05) | P = 0.027 | |
Macrophages TNFR1 (2 − ∆Ct) | 0.008 (0.005-0.01) | 0.006 (0.005-0.016) | 0.004*# (0.004-0.005) | P = 0.037 | |
Macrophages TNFR2 (2 − ∆Ct) | 0.003 (0.001-0.003) | 0.003 (0.003-0.004) | 0.002 (0.001-0.002) | P = 0.055 |