Table 5 Between- and within-subjects variability in the annual change in bronchodilator response expressed as absolute, relative and percent predicted changes 1
Response measured by absolute change in FEV (ml) | Response measured by absolute change in FVC (ml) | |||
|---|---|---|---|---|
Tiotropium | Placebo | Tiotropium | Placebo | |
Between-subject variability in annual change (square-root of variance) | 15.2 | 15.3 | 30.2 | 44.5 |
Within-subject variability (square-root of variance) | 109.2 | 107.9 | 244.7 | 252.0 |
Response measured by % change in FEV (ml) | Response measured by % change in FVC (ml) | |||
Tiotropium | Placebo | Tiotropium | Placebo | |
Between-subject variability in annual change (square-root of variance) | 1.44 | 1.65 | 1.43 | 1.98 |
Within-subject variability (square-root of variance) | 11.3 | 12.0 | 11.0 | 12.4 |
Response measured by absolute change in FEV (% predicted) | Response measured by absolute change in FVC (% predicted) | |||
Tiotropium | Placebo | Tiotropium | Placebo | |
Between-subject variability in annual change (square-root of variance) | 0.55 | 0.54 | 0.89 | 1.26 |
Within-subject variability (square-root of variance) | 3.93 | 3.88 | 7.04 | 7.23 |