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Table 1 Respiratory and haemodynamic data

From: Low tidal volume pressure support versus controlled ventilation in early experimental sepsis in pigs

Variables VCV PSV Group effect
Baseline 3 h 6 h Baseline 3 h 6 h
FiO2 [%] 36 ± 1 47 ± 13 56 ± 18 36 ± 1 43 ± 11 52 ± 25 n.s.
Ppeak [cm H2O] 17 ± 2 23 ± 5 26 ± 6 16 ± 2 20 ± 4 25 ± 9 n.s.
Pmean [cm H2O] 9 ± 1 13 ± 3 15 ± 5 9 ± 1 10 ± 3 13 ± 6 n.s.
PEEP [cmH2O] 7 ± 1 10 ± 4 12 ± 5 7 ± 1 5 ± 2 9 ± 5 n.s.
ΔPes [cm H2O] 0 ± 0 0 ± 2 0 ± 1 0 ± 0 0 ± 1 0 ± 1 n.s.
Ptp [cm H2O] 7 ± 2 6 ± 1 6 ± 1 6 ± 1 7 ± 1 7 ± 1 n.s.
Vt [ml kg-1] 6.8 ± 2.1 5.3 ± 2.0 5.5 ± 2.1 6.2 ± 0.5 6.5 ± 0.6 7.1 ± 1.2 n.s.
RR [min-1] 36 ± 8 45 ± 5 46 ± 5 39 ± 5 39 ± 15 37 ± 10 p = 0.04
Cdyn [ml cm H2O-1] 32 ± 11 14 ± 8 14 ± 6 33 ± 14 14 ± 4 13 ± 4 n.s.
pH 7.38 ± 0.04 7.17 ± 0.09 7.25 ± 0.08 7.34 ± 0.06 7.21 ± 0.04 7.19 ± 0.11 n.s.
AaDO2 [mmHg] 42 ± 19 174 ± 86 229 ± 138 48 ± 26 167 ± 90 214 ± 158 n.s.
etCO2 [kPa] 5.5 ± 0.4 5.5 ± 0.5 4.7 ± 0.6 5.3 ± 0.3 6.2 ± 1.1 7.8 ± 4.5 p = 0.02
HR [min-1] 106 ± 20 141 ± 27 127 ± 25 103 ± 24 132 ± 22 127 ± 25 n.s.
MAP [mmHg] 96 ± 6 68 ± 11 73 ± 13 90 ± 10 66 ± 7 72 ± 14 n.s.
MPAP [mmHg] 26 ± 6 46 ± 5 38 ± 5 26 ± 4 43 ± 7 35 ± 10 n.s.
CVP [mmHg] 14 ± 3 14 ± 3 15 ± 1 14 ± 1 13 ± 1 14 ± 2 n.s.
CO [L min-1] 4.2 ± 0.7 3.1 ± 0.6 2.6 ± 0.6 4.2 ± 1.3 3.3 ± 0.8 3.2 ± 0.7 n.s.
SVR [dyn s cm-5] 1570 ± 313 1493 ± 484 1916 ± 417 1547 ± 405 1402 ± 397 1427 ± 185 n.s.
NA [μg kg-1 min-1] 0 ± 0 0.2 ± 0.3 0.3 ± 0.3 0 ± 0 0.1 ± 0.2 0.2 ± 0.3 n.s.
  1. Data are reported as mean ± SD. Group effects over time are analyzed by two-way-ANOVA and with Holm-Sidak procedure. No intergroup differences during baseline. n.s. = non-significant.
  2. FiO2: fraction of inspired oxygen; Ppeak: peak inspiratory pressure; Pmean: mean airway pressure; PEEP: positive end-expiratory pressure, ΔPes: difference of the esophageal pressure; Ptp: transpulmonary pressure; Vt: tidal volume; RR: respiratory rate; Cdyn: dynamic lung compliance; AaDO2: alveolar-arterial oxygen difference; etCO2: endtidal carbon dioxide; HR: heart rate; MAP: mean arterial pressure; MPAP: mean pulmonary arterial pressure; CVP: central venous pressure; CO: cardiac output; SVR: systemic vascular resistance; NA: noradrenaline dosage.