From: Low tidal volume pressure support versus controlled ventilation in early experimental sepsis in pigs
Variables | VCV | PSV | Group effect | ||||
---|---|---|---|---|---|---|---|
Baseline | 3 h | 6 h | Baseline | 3 h | 6 h | ||
FiO2 [%] | 36 ± 1 | 47 ± 13 | 56 ± 18 | 36 ± 1 | 43 ± 11 | 52 ± 25 | n.s. |
Ppeak [cm H2O] | 17 ± 2 | 23 ± 5 | 26 ± 6 | 16 ± 2 | 20 ± 4 | 25 ± 9 | n.s. |
Pmean [cm H2O] | 9 ± 1 | 13 ± 3 | 15 ± 5 | 9 ± 1 | 10 ± 3 | 13 ± 6 | n.s. |
PEEP [cmH2O] | 7 ± 1 | 10 ± 4 | 12 ± 5 | 7 ± 1 | 5 ± 2 | 9 ± 5 | n.s. |
ΔPes [cm H2O] | 0 ± 0 | 0 ± 2 | 0 ± 1 | 0 ± 0 | 0 ± 1 | 0 ± 1 | n.s. |
Ptp [cm H2O] | 7 ± 2 | 6 ± 1 | 6 ± 1 | 6 ± 1 | 7 ± 1 | 7 ± 1 | n.s. |
Vt [ml kg-1] | 6.8 ± 2.1 | 5.3 ± 2.0 | 5.5 ± 2.1 | 6.2 ± 0.5 | 6.5 ± 0.6 | 7.1 ± 1.2 | n.s. |
RR [min-1] | 36 ± 8 | 45 ± 5 | 46 ± 5 | 39 ± 5 | 39 ± 15 | 37 ± 10 | p = 0.04 |
Cdyn [ml cm H2O-1] | 32 ± 11 | 14 ± 8 | 14 ± 6 | 33 ± 14 | 14 ± 4 | 13 ± 4 | n.s. |
pH | 7.38 ± 0.04 | 7.17 ± 0.09 | 7.25 ± 0.08 | 7.34 ± 0.06 | 7.21 ± 0.04 | 7.19 ± 0.11 | n.s. |
AaDO2 [mmHg] | 42 ± 19 | 174 ± 86 | 229 ± 138 | 48 ± 26 | 167 ± 90 | 214 ± 158 | n.s. |
etCO2 [kPa] | 5.5 ± 0.4 | 5.5 ± 0.5 | 4.7 ± 0.6 | 5.3 ± 0.3 | 6.2 ± 1.1 | 7.8 ± 4.5 | p = 0.02 |
HR [min-1] | 106 ± 20 | 141 ± 27 | 127 ± 25 | 103 ± 24 | 132 ± 22 | 127 ± 25 | n.s. |
MAP [mmHg] | 96 ± 6 | 68 ± 11 | 73 ± 13 | 90 ± 10 | 66 ± 7 | 72 ± 14 | n.s. |
MPAP [mmHg] | 26 ± 6 | 46 ± 5 | 38 ± 5 | 26 ± 4 | 43 ± 7 | 35 ± 10 | n.s. |
CVP [mmHg] | 14 ± 3 | 14 ± 3 | 15 ± 1 | 14 ± 1 | 13 ± 1 | 14 ± 2 | n.s. |
CO [L min-1] | 4.2 ± 0.7 | 3.1 ± 0.6 | 2.6 ± 0.6 | 4.2 ± 1.3 | 3.3 ± 0.8 | 3.2 ± 0.7 | n.s. |
SVR [dyn s cm-5] | 1570 ± 313 | 1493 ± 484 | 1916 ± 417 | 1547 ± 405 | 1402 ± 397 | 1427 ± 185 | n.s. |
NA [μg kg-1 min-1] | 0 ± 0 | 0.2 ± 0.3 | 0.3 ± 0.3 | 0 ± 0 | 0.1 ± 0.2 | 0.2 ± 0.3 | n.s. |