Figure 3
Comparison between S-1226 and other bronchodilators in the sheep model of asthma. This figure shows the % decline in lung resistance following treatment with S-1226, 12% CO2, perflubron, salbutamol, medical air or no treatment in HDM challenged sheep. Measurements were taken immediately, 1–10 minutes and 10–20 minutes after treatment. Treatment with S-1226 showed significant and sustained declines in lung resistance compared to medical air or no treatment. In addition S-1226 showed a significantly greater decline in lung resistance compared to salbutamol. P-values show significant difference from S-1226; *p <0.05, # p ≤ 0.01.