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Table 3 Aging genes differentially expressed in the small airway epithelium of healthy smokers vs healthy nonsmokers 1

From: Smoking accelerates aging of the small airway epithelium

Direction of expression with smoking Gene symbol Gene title Fold-change2 p value3 Direction of expression with aging4
Up-regulated SPP1 Secreted phosphoprotein 1 13.48 3.1x10-5 Over
  LAPTM5 Lysosomal protein transmembrane 5 1.75 3.8x10-2 Over
  ANXA3 Annexin A3 1.72 2.2x10-3 Over
  MPEG1 Macrophage expressed 1 1.59 1.3x10-2 Over
  MGST1 Microsomal glutathione S-transferase 1 1.40 2.4x10-4 Over
  MSN Moesin 1.39 2.6x10-2 Over
  CLU Clusterin 1.38 3.6x10-3 Over
  COL3A1 Collagen, type III, alpha 1 1.34 4.3x10-2 Under
  FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.32 3.4x10-2 Over
  GSTA1 Glutathione S-transferase alpha 1 1.31 3.8x10-4 Over
  LITAF Lipopolysaccharide-induced TNF factor 1.26 3.2x10-4 Over
  GHITM Growth hormone inducible transmembrane protein 1.25 3.1x10-5 Under
  VAT1 Vesicle amine transport protein 1 homolog (T. californica) 1.22 4.3x10-3 Over
Down-regulated MT1F Metallothionein 1 F -1.60 3.1x10-5 Over
  PCSK6 Proprotein convertase subtilisin/kexin type 6 -1.63 4.7x10-4 Over
  C4A Complement component 4A -2.45 3.2x10-4 Under
  CX3CL1 Chemokine (C-X3-C motif) ligand 1 -2.50 3.0x10-6 Under
  C3 Complement component 3 -2.73 2.1x10-3 Over
  1. 1List of aging genes based on de Magalhaes et al. [26]; listed are the genes with significantly different expression in the small airway epithelium of healthy smokers vs healthy nonsmokers; for the data for all of the de Magalhaes et al. “aging genes”, see Additional file 1: Table S1.
  2. 2Fold-change - mean in healthy smokers/mean in healthy nonsmokers.
  3. 3False discovery rate, p < 0.05, Partek Benjamini-Hochberg correction.
  4. 4Direction of expression observed with aging, see de Magalhaes et al. [26].