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Table 3 Aging genes differentially expressed in the small airway epithelium of healthy smokers vs healthy nonsmokers 1

From: Smoking accelerates aging of the small airway epithelium

Direction of expression with smoking

Gene symbol

Gene title

Fold-change2

p value3

Direction of expression with aging4

Up-regulated

SPP1

Secreted phosphoprotein 1

13.48

3.1x10-5

Over

 

LAPTM5

Lysosomal protein transmembrane 5

1.75

3.8x10-2

Over

 

ANXA3

Annexin A3

1.72

2.2x10-3

Over

 

MPEG1

Macrophage expressed 1

1.59

1.3x10-2

Over

 

MGST1

Microsomal glutathione S-transferase 1

1.40

2.4x10-4

Over

 

MSN

Moesin

1.39

2.6x10-2

Over

 

CLU

Clusterin

1.38

3.6x10-3

Over

 

COL3A1

Collagen, type III, alpha 1

1.34

4.3x10-2

Under

 

FCGR2B

Fc fragment of IgG, low affinity IIb, receptor (CD32)

1.32

3.4x10-2

Over

 

GSTA1

Glutathione S-transferase alpha 1

1.31

3.8x10-4

Over

 

LITAF

Lipopolysaccharide-induced TNF factor

1.26

3.2x10-4

Over

 

GHITM

Growth hormone inducible transmembrane protein

1.25

3.1x10-5

Under

 

VAT1

Vesicle amine transport protein 1 homolog (T. californica)

1.22

4.3x10-3

Over

Down-regulated

MT1F

Metallothionein 1 F

-1.60

3.1x10-5

Over

 

PCSK6

Proprotein convertase subtilisin/kexin type 6

-1.63

4.7x10-4

Over

 

C4A

Complement component 4A

-2.45

3.2x10-4

Under

 

CX3CL1

Chemokine (C-X3-C motif) ligand 1

-2.50

3.0x10-6

Under

 

C3

Complement component 3

-2.73

2.1x10-3

Over

  1. 1List of aging genes based on de Magalhaes et al. [26]; listed are the genes with significantly different expression in the small airway epithelium of healthy smokers vs healthy nonsmokers; for the data for all of the de Magalhaes et al. “aging genes”, see Additional file 1: Table S1.
  2. 2Fold-change - mean in healthy smokers/mean in healthy nonsmokers.
  3. 3False discovery rate, p < 0.05, Partek Benjamini-Hochberg correction.
  4. 4Direction of expression observed with aging, see de Magalhaes et al. [26].