From: Smoking accelerates aging of the small airway epithelium
Direction of expression with smoking | Gene symbol | Gene title | Fold-change2 | p value3 | Direction of expression with aging4 |
---|---|---|---|---|---|
Up-regulated | SPP1 | Secreted phosphoprotein 1 | 13.48 | 3.1x10-5 | Over |
LAPTM5 | Lysosomal protein transmembrane 5 | 1.75 | 3.8x10-2 | Over | |
ANXA3 | Annexin A3 | 1.72 | 2.2x10-3 | Over | |
MPEG1 | Macrophage expressed 1 | 1.59 | 1.3x10-2 | Over | |
MGST1 | Microsomal glutathione S-transferase 1 | 1.40 | 2.4x10-4 | Over | |
MSN | Moesin | 1.39 | 2.6x10-2 | Over | |
CLU | Clusterin | 1.38 | 3.6x10-3 | Over | |
COL3A1 | Collagen, type III, alpha 1 | 1.34 | 4.3x10-2 | Under | |
FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 1.32 | 3.4x10-2 | Over | |
GSTA1 | Glutathione S-transferase alpha 1 | 1.31 | 3.8x10-4 | Over | |
LITAF | Lipopolysaccharide-induced TNF factor | 1.26 | 3.2x10-4 | Over | |
GHITM | Growth hormone inducible transmembrane protein | 1.25 | 3.1x10-5 | Under | |
VAT1 | Vesicle amine transport protein 1 homolog (T. californica) | 1.22 | 4.3x10-3 | Over | |
Down-regulated | MT1F | Metallothionein 1 F | -1.60 | 3.1x10-5 | Over |
PCSK6 | Proprotein convertase subtilisin/kexin type 6 | -1.63 | 4.7x10-4 | Over | |
C4A | Complement component 4A | -2.45 | 3.2x10-4 | Under | |
CX3CL1 | Chemokine (C-X3-C motif) ligand 1 | -2.50 | 3.0x10-6 | Under | |
C3 | Complement component 3 | -2.73 | 2.1x10-3 | Over |