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Table 2 Demographics of the study population and biologic samples for telomere length analysis in the small airway epithelium 1

From: Smoking accelerates aging of the small airway epithelium

Parameter

Healthy nonsmokers

Healthy smokers

p value6

n

21

22

 

Gender

All male

All male

 

Age (yr)

39.0 ± 12.9

43.9 ± 7.6

>0.14

Race (B/W/O)2

8/6/7

14/3/5

 

Smoking history (pack-yr)

0

22.6 ± 9.0

 

Urine nicotine (ng/ml)

negative

1424 ± 1432

 

Urine cotinine (ng/ml)

negative

1359 ± 993

 

Pulmonary function parameters3

   

FVC

103.1 ± 10.9

110.4 ± 8.5

<0.03

FEV1

105.4 ± 11.1

107.5 ± 8.2

>0.48

FEV1/FVC

83.9 ± 4.8

79.1 ± 3.7

<0.002

TLC

102.0 ± 14.6

96.2 ± 12.7

>0.17

DLCO

93.3 ± 11.8

87.2 ± 7.7

>0.05

Body mass index (BMI)

27.8 ± 4.5

26.0 ± 3.9

>0.16

Epithelial cells4

   

% epithelial cells

97.5 ± 1.4

99.1 ± 0.8

<0.0001

% inflammatory cells

2.5 ± 1.4

0.9 ± 0.8

<0.0001

Differential cell count5

   

Ciliated (%)

62.3 ± 5.8

57.9 ± 7.1

<0.03

Secretory (%)

11.0 ± 5.1

17.3 ± 6.0

<0.0006

Basal (%)

5.8 ± 4.2

5.6 ± 4.5

>0.97

Undifferentiated columnar (%)

18.4 ± 5.8

18.3 ± 8.6

>0.90

  1. 1Data is presented as mean ± standard deviation.
  2. 2B = Black, W = White, O = Other.
  3. 3Pulmonary function testing parameters are given as % predicted value with the exception of FEV1/FVC, which is reported as % observed; FVC - forced vital capacity, FEV1 - forced expiratory volume in 1 sec. FVC, FEV1 and FEV1/FVC are post-bronchodilator values. TLC - total lung capacity, DLCO - diffusing capacity of the lung for carbon monoxide.
  4. 4Small airway epithelium.
  5. 5As % of small airway epithelium recovered.
  6. 6Smoker vs Nonsmoker comparison by student’s ttest with p < 0.05 being significant.