From: Smoking accelerates aging of the small airway epithelium
Parameter | Healthy nonsmokers | Healthy smokers | p value6 |
---|---|---|---|
n | 21 | 22 | Â |
Gender | All male | All male | Â |
Age (yr) | 39.0 ± 12.9 | 43.9 ± 7.6 | >0.14 |
Race (B/W/O)2 | 8/6/7 | 14/3/5 | Â |
Smoking history (pack-yr) | 0 | 22.6 ± 9.0 |  |
Urine nicotine (ng/ml) | negative | 1424 ± 1432 |  |
Urine cotinine (ng/ml) | negative | 1359 ± 993 |  |
Pulmonary function parameters3 | Â | Â | Â |
FVC | 103.1 ± 10.9 | 110.4 ± 8.5 | <0.03 |
FEV1 | 105.4 ± 11.1 | 107.5 ± 8.2 | >0.48 |
FEV1/FVC | 83.9 ± 4.8 | 79.1 ± 3.7 | <0.002 |
TLC | 102.0 ± 14.6 | 96.2 ± 12.7 | >0.17 |
DLCO | 93.3 ± 11.8 | 87.2 ± 7.7 | >0.05 |
Body mass index (BMI) | 27.8 ± 4.5 | 26.0 ± 3.9 | >0.16 |
Epithelial cells4 | Â | Â | Â |
% epithelial cells | 97.5 ± 1.4 | 99.1 ± 0.8 | <0.0001 |
% inflammatory cells | 2.5 ± 1.4 | 0.9 ± 0.8 | <0.0001 |
Differential cell count5 | Â | Â | Â |
Ciliated (%) | 62.3 ± 5.8 | 57.9 ± 7.1 | <0.03 |
Secretory (%) | 11.0 ± 5.1 | 17.3 ± 6.0 | <0.0006 |
Basal (%) | 5.8 ± 4.2 | 5.6 ± 4.5 | >0.97 |
Undifferentiated columnar (%) | 18.4 ± 5.8 | 18.3 ± 8.6 | >0.90 |