Skip to main content

Advertisement

Table 2 Demographics of the study population and biologic samples for telomere length analysis in the small airway epithelium 1

From: Smoking accelerates aging of the small airway epithelium

Parameter Healthy nonsmokers Healthy smokers p value6
n 21 22  
Gender All male All male  
Age (yr) 39.0 ± 12.9 43.9 ± 7.6 >0.14
Race (B/W/O)2 8/6/7 14/3/5  
Smoking history (pack-yr) 0 22.6 ± 9.0  
Urine nicotine (ng/ml) negative 1424 ± 1432  
Urine cotinine (ng/ml) negative 1359 ± 993  
Pulmonary function parameters3    
FVC 103.1 ± 10.9 110.4 ± 8.5 <0.03
FEV1 105.4 ± 11.1 107.5 ± 8.2 >0.48
FEV1/FVC 83.9 ± 4.8 79.1 ± 3.7 <0.002
TLC 102.0 ± 14.6 96.2 ± 12.7 >0.17
DLCO 93.3 ± 11.8 87.2 ± 7.7 >0.05
Body mass index (BMI) 27.8 ± 4.5 26.0 ± 3.9 >0.16
Epithelial cells4    
% epithelial cells 97.5 ± 1.4 99.1 ± 0.8 <0.0001
% inflammatory cells 2.5 ± 1.4 0.9 ± 0.8 <0.0001
Differential cell count5    
Ciliated (%) 62.3 ± 5.8 57.9 ± 7.1 <0.03
Secretory (%) 11.0 ± 5.1 17.3 ± 6.0 <0.0006
Basal (%) 5.8 ± 4.2 5.6 ± 4.5 >0.97
Undifferentiated columnar (%) 18.4 ± 5.8 18.3 ± 8.6 >0.90
  1. 1Data is presented as mean ± standard deviation.
  2. 2B = Black, W = White, O = Other.
  3. 3Pulmonary function testing parameters are given as % predicted value with the exception of FEV1/FVC, which is reported as % observed; FVC - forced vital capacity, FEV1 - forced expiratory volume in 1 sec. FVC, FEV1 and FEV1/FVC are post-bronchodilator values. TLC - total lung capacity, DLCO - diffusing capacity of the lung for carbon monoxide.
  4. 4Small airway epithelium.
  5. 5As % of small airway epithelium recovered.
  6. 6Smoker vs Nonsmoker comparison by student’s ttest with p < 0.05 being significant.