Figure 1

Smoking dysregulated genes in the small airway epithelium. A. Volcano plot, smoker vs nonsmoker small airway epithelium (n = 29 nonsmokers and n = 29 smokers) using all expressed (P call ≥10) probesets as input dataset. Ordinate - p value; abscissa - fold-change (log₂). Data demonstrates 2488 smoking-dysregulated probesets [fold-change ≥1.2, p < 0.05 with false discovery rate (FDR) correction] representing a total of 1737 unique genes. B. Hierarchical cluster analysis of smoker vs nonsmoker small airway epithelium based on expression of 2488 smoking-dysregulated probesets [fold-change ≥1.2, p < 0.05 with false discovery rate (FDR) correction]. Probesets expressed above the average are represented in red, below average in blue and average in grey. The probesets are represented horizontally and individual samples vertically.