Figure 7

Blocking p38 activation by treatment with the selective inhibitor SB203580 decreases GLP-induced p38 phosphorylation and IL-6 production. Cultured cell lysates were prepared after incubation with SB203580 and GLP for 30 min, as detailed in the Methods section. Cultured cell were incubated with GLP for up to 24 h to measure the IL-6 level in the supernatant (A). *P < 0.05 compared to the control group; ^#P < 0.05 compared to the GLP group.