Figure 2
Lipis body formation and lipid mediators production in BALF of SW mice 24 h after intra-tracheal challenge with ouabain (0.075 μmol/animal) or GLP (12 μg of GLP protein/animal). Lipid body numbers (A), PGE2 concentrations (B) and LTB4 concentrations (C) in BALF of SW mice 24 h after intra-tracheal challenge with ouabain (0.075 μmol/animal) or GLP (12 μg of GLP protein/animal). Controls received 50 μL of sterile saline. Number of leukocyte lipid bodies and the production of LTB4 and IL-1β in BALF supernatants of C57BL/10 and C57BL/10ScCr mice 24 h after intra-tracheal challenge with LPS (500 ng/animal) or GLP (12 μg of GLP protein/animal). Controls received 50 μL of sterile saline. Controls (white bars), LPS-treated (gray bars), and GLP-treated (black bars). (D) Lipid bodies, (E) LTB4 and (F) IL-1β. The results are the means ± SEM of 6 to 8 animals per group. *P < 0.05 compared to the control group; #P < 0.05 when both strains were compared.