Figure 7
From: Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice
The anti-fibrotic effects of long-term treatment with a NO donor in a pulmonary fibrosis model at two weeks after BLM-treatment (n = 4-5). (A) Hematoxylin-eosin staining, Masson-trichrome staining. Scale bar = 100 μm. (B) The fibrotic tissue area (blue-stained). (C) The serum NOx levels. White and black bars indicate normal saline (NS)- and BLM- treated mice, respectively. (D) The collagen content in lung tissue. *P < 0.05 vs. the BLM-treated WT mice. #P < 0.05 vs. the BLM-treated n/i/e NOS−/− mice that received ISDN. †P < 0.05 vs. the NS-treated mice.