Table 2 Significant predictors of P reserved R atio I mpaired S piro m etry (PRISm) status relative to control subjects in (a) fixed threshold-defined and (b) lower limit of normal (LLN)-defined cohorts in multivariate models

Pack-years

1.008 [1.005-1.012]

Pack-years

1.008 [1.004-1.012]

Resting oxygen saturation

0.907 [0.875-0.940]

Resting oxygen saturation

0.931 [0.897-0.966]

6 minute walk distance (per 100 feet)

0.948 [0.926-0.971]

6 minute walk distance (per 100 feet)

0.953 [0.929-0.977]

MMRC Dyspnea score

1.226 [1.153-1.304]

MMRC Dyspnea score

1.192 [1.116-1.273]

Percent emphysema

1.055 [1.020-1.091]

Percent emphysema

1.061 [1.029-1.094]

Total lung capacity% predicted

0.949 [0.943-0.955]

Total lung capacity% predicted

0.948 [0.942-0.954]

Segmental wall area percent

1.203 [1.168-1.238]

Segmental wall area percent

1.190 [1.154-1.227]

Peripheral vascular disease

1.777 [1.038-3.043]

Peripheral vascular disease

2.038 [1.254-3.314]

Physician-diagnosed asthma

1.391 [1.126-1.718]

Physician-diagnosed asthma

1.485 [1.193-1.848]

Age

1.025 [1.014-1.035]

Diabetes Mellitus

1.372 [1.111-1.695]

Sex (male)

0.705 [0.598-0.833]

African American race

0.266 [0.216-0.328]

Hyperlipidemia

1.216 [1.031-1.433]

Body mass index

1.026 [1.012-1.040]

Current smoking

1.620 [1.337-1.962]

Coronary artery disease

1.370 [1.002-1.874]