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Table 2 Significant predictors of P reserved R atio I mpaired S piro m etry (PRISm) status relative to control subjects in (a) fixed threshold-defined and (b) lower limit of normal (LLN)-defined cohorts in multivariate models

From: Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene

Panel (a) – significant predictors in fixed threshold- defined cohorts Panel (b) – significant predictors in LLN defined cohorts
Predictor OR [95% CI] Predictor OR [95% CI]
Pack-years 1.008 [1.005-1.012] Pack-years 1.008 [1.004-1.012]
Resting oxygen saturation 0.907 [0.875-0.940] Resting oxygen saturation 0.931 [0.897-0.966]
6 minute walk distance (per 100 feet) 0.948 [0.926-0.971] 6 minute walk distance (per 100 feet) 0.953 [0.929-0.977]
MMRC Dyspnea score 1.226 [1.153-1.304] MMRC Dyspnea score 1.192 [1.116-1.273]
Percent emphysema 1.055 [1.020-1.091] Percent emphysema 1.061 [1.029-1.094]
Total lung capacity% predicted 0.949 [0.943-0.955] Total lung capacity% predicted 0.948 [0.942-0.954]
Segmental wall area percent 1.203 [1.168-1.238] Segmental wall area percent 1.190 [1.154-1.227]
Peripheral vascular disease 1.777 [1.038-3.043] Peripheral vascular disease 2.038 [1.254-3.314]
Physician-diagnosed asthma 1.391 [1.126-1.718] Physician-diagnosed asthma 1.485 [1.193-1.848]
Age 1.025 [1.014-1.035] Diabetes Mellitus 1.372 [1.111-1.695]
Sex (male) 0.705 [0.598-0.833] African American race 0.266 [0.216-0.328]
Hyperlipidemia 1.216 [1.031-1.433] Body mass index 1.026 [1.012-1.040]
   Current smoking 1.620 [1.337-1.962]
   Coronary artery disease 1.370 [1.002-1.874]
  1. Variables tested but not retained in the final models:
  2. Panel (a): body mass index, Pi10, current smoking, chronic bronchitis, bronchodilator responsiveness, congestive heart failure, coronary artery disease, diabetes, hypertension, history of blood clots, stroke, gastro-esophageal reflux disease, compression fractures, and current employment.
  3. Panel (b): age, Pi10, chronic bronchitis, bronchodilator responsiveness, congestive heart failure, hypertension, hyperlipidemia, history of blood clots, stroke, gastro-esophageal reflux disease, compression fractures, and current employment.
  4. No significant confounders (defined as causing >10% change in effect estimate) were found.