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Table 2 Median values (ranges) of spontaneous and lipopolysaccharide-induced tumour necrosis factor-α secretion

From: Tumour necrosis factor-α production in fibrosing alveolitis is macrophage subset specific

 

FA

SSc no FA

Normal

 

Without LPS

With LPS

Without LPS

With LPS

Without LPS

With LPS

AM

      

   APA (μm2)

1325

1500

1173

1327

1184

1377

 

(1077–2240)

(1277–2281)

(914–1326)

(1230–1586)

(1024–1332)

(1186–1572)

   %PFC

19.8

23.7

12.5

17.7

12.0

16.5

 

(12.0–30.6)

(18–32)

(8–14)

(14–22)

(9–18.7)

(14–21.3)

   TPA (μm2)

25225

36722

14225

25657

14829

24011

 

(14532–56009)

(24928–69498)

(7500–18564)

(17836–30807)

(9783–22507)

(16604–31480)

Mo

      

   APA (μm2)

983

1251

1013

1247

1042

1222

 

(789–1445)

(998–1550)

(864–1277)

(1022–1363)

(742–1220)

(897–1369)

   %PFC

9.3

18

9.7

16.4

10

18

 

(6–13)

(10–26)

(7.6–13)

(14–22)

(6–13)

(14–21.6)

   TPA (μm2)

9638

23271

10007

21158

9638

20546

 

(5118–13960)

(15444–41000)

(7200–14800)

(14310–27650)

(6576–13980)

(12558–28651)

  1. AM = alveolar macrophages; APA = average plaque area; FA = fibrosing alveolitis; LPS = lipopolysaccharide; Mo = peripheral blood monocytes; %PFC = percentage of plaque forming cells; SSc = systemic sclerosis; TPA = Total plaque area.