Skip to main content
Figure 1 | Respiratory Research

Figure 1

From: Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease

Figure 1

Post-partial pneumonectomy (PNX) compensatory lung growth in male C57Bl/6 mice. Anesthetized male C57Bl/6 mice were subjected to either a left PNX or a sham thorocotomy (SHAM). On specific days following surgery, animals were sacrificed and lungs were removed; right lung weight (RLW) and total lung weight (TLW) were recorded. Lung weight (LW) was normalized to body weight (BW) and plotted as a function of post-surgical day. In mice subjected to SHAM surgery, both the TLW/BW and RLW/BW ratios declined over the 10-day study. Following resection of the left lung, the RLW/BW ratio increased in a linear manner between post-surgical days 1 and 10. On post-surgical day 5, the PNX RLW/BW ratio was 5.2 ± 0.1 mg/g, a value statistically greater than the RLW/BW ratio in SHAM animals (P < 0.001). The PNX RLW/BW ratio was equivalent to the TLW/BW ratio in SHAM-operated animals by day 10. PNX mice gained 40.3 mg right lung tissue by day 10 at a rate of 4.3 mg tissue per day. Data represent the mean ± SE of one experiment where n = 5-8. Where error bars do not appear, they do not extend beyond the symbol.

Back to article page