Figure 2From: Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell diseaseMechanism by which free radicals alter NO bioavailability and endothelial cell biology. Under conditions of increased O2- production, NO preferentially forms ONOO-. Both O2- and ONOO- can alter endothelial cell (EC) gene expression via activation and nuclear translocation of second messengers such as NF-κB.Back to article page