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Table 2 The association of GSTP1 genotype with atopic status and degree of airway reactivity/obstruction

From: Simultaneous identification of GSTP1 Ile105→Val105 and Ala114→Val114 substitutions using an amplification refractory mutation systempolymerase chain reactionassay: studies in patients with asthma

 

Total

Skin test

Skin test

IgE ≤

IgE >

    

Genotype

group

negative

positive

100 IU/ml

100 IU/ml

Group 1

Group 2

Group 3

Group 4

AA

79 (42.4)

29 (40.9)

50 (41.7)

42 (43.3)

27 (38.6)

17 (29.3)

4 (26.7)

21 (41.2)

23 (48.9)

AB

66 (34.6)

21 (29.6)

45 (37.5)

30 (30.9)

30 (42.9)

24 (41.4)

6 (40.0)

21 (41.2)

14 (29.8)

AC

26 (13.6)

10 (14.1)

16 (13.3)

11 (11.3)

11 (15.7)

7 (12.1)

3 (20.0)

6 (11.8)

7 (14.9)

AD

2 (1.1)

0 (0)

2 (1.7)

1 (1.0)

1 (1.4)

1 (1.7)

0 (0)

0 (0)

1 (2.1)

BB

7 (3.7)

4 (5.6)

3 (2.5)

5 (5.2)

0 (0)

3 (5.2)

1 (6.7)

1 (2.0)

1 (2.1)

BC

9 (4.7)

7 (9.9)

2 (1.7)*

7 (7.2)

0 (0)

5 (8.6)

1 (6.7)

1 (2.0)

1 (2.1)

BD

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

CC

2 (1.1)

0 (0)

2 (1.7)

1 (1.0)

1 (1.4)

1 (1.7)

0 (0)

1 (2.0)

0 (0)

CD

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

DD

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

Alleles

         

   GSTP1*A

0.660

0.627

0.679

0.649

0.686

0.569

0.567

0.676

0.731

   GSTP1*B

0.233

0.254

0.221

0.242

0.214

0.302

0.300

0.235

0.172

   GSTP1*C

0.102

0.120

0.092

0.103

0.093

0.121

0.133

0.088

0.086

   GSTP1*D

0.005

0

0.008

0.005

0.007

0.009

0

0

0.011

  1. Atopic status was defined as positive skin test and IgE 100 IU/ml or less. Groups were defined as follows: group 1, percentage predicted >80%/PC20 >16 mg/ml; group 2, percentage predicted >80%/PC20 8-16 mg/ml; group 3, percentage predicted >80%/PC20 0-8 mg/ml; and group 4, percentage predicted ≤ 80%. Values are expressed as number (%) for the genotype frequencies, or as proportions for the allele frequencies.*Logistic regression analysis for skin test: uncorrected GSTP1 BC versus GSTP1 AA, OR 0.17, 95% CI 0.03-0.85 (P = 0.031); and corrected for age and sex, OR 0.18, 95% CI 0.04-0.96 (P = 0.045). Trend test analysis across groups 1-4: uncorrected GSTP1 BC versus GSTP1AA, P = 0.031; and corrected for age and sex, P = 0.02.