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Table 2 The association of GSTP1 genotype with atopic status and degree of airway reactivity/obstruction

From: Simultaneous identification of GSTP1 Ile105→Val105 and Ala114→Val114 substitutions using an amplification refractory mutation systempolymerase chain reactionassay: studies in patients with asthma

  Total Skin test Skin test IgE ≤ IgE >     
Genotype group negative positive 100 IU/ml 100 IU/ml Group 1 Group 2 Group 3 Group 4
AA 79 (42.4) 29 (40.9) 50 (41.7) 42 (43.3) 27 (38.6) 17 (29.3) 4 (26.7) 21 (41.2) 23 (48.9)
AB 66 (34.6) 21 (29.6) 45 (37.5) 30 (30.9) 30 (42.9) 24 (41.4) 6 (40.0) 21 (41.2) 14 (29.8)
AC 26 (13.6) 10 (14.1) 16 (13.3) 11 (11.3) 11 (15.7) 7 (12.1) 3 (20.0) 6 (11.8) 7 (14.9)
AD 2 (1.1) 0 (0) 2 (1.7) 1 (1.0) 1 (1.4) 1 (1.7) 0 (0) 0 (0) 1 (2.1)
BB 7 (3.7) 4 (5.6) 3 (2.5) 5 (5.2) 0 (0) 3 (5.2) 1 (6.7) 1 (2.0) 1 (2.1)
BC 9 (4.7) 7 (9.9) 2 (1.7)* 7 (7.2) 0 (0) 5 (8.6) 1 (6.7) 1 (2.0) 1 (2.1)
BD 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
CC 2 (1.1) 0 (0) 2 (1.7) 1 (1.0) 1 (1.4) 1 (1.7) 0 (0) 1 (2.0) 0 (0)
CD 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
DD 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
Alleles          
   GSTP1*A 0.660 0.627 0.679 0.649 0.686 0.569 0.567 0.676 0.731
   GSTP1*B 0.233 0.254 0.221 0.242 0.214 0.302 0.300 0.235 0.172
   GSTP1*C 0.102 0.120 0.092 0.103 0.093 0.121 0.133 0.088 0.086
   GSTP1*D 0.005 0 0.008 0.005 0.007 0.009 0 0 0.011
  1. Atopic status was defined as positive skin test and IgE 100 IU/ml or less. Groups were defined as follows: group 1, percentage predicted >80%/PC20 >16 mg/ml; group 2, percentage predicted >80%/PC20 8-16 mg/ml; group 3, percentage predicted >80%/PC20 0-8 mg/ml; and group 4, percentage predicted ≤ 80%. Values are expressed as number (%) for the genotype frequencies, or as proportions for the allele frequencies.*Logistic regression analysis for skin test: uncorrected GSTP1 BC versus GSTP1 AA, OR 0.17, 95% CI 0.03-0.85 (P = 0.031); and corrected for age and sex, OR 0.18, 95% CI 0.04-0.96 (P = 0.045). Trend test analysis across groups 1-4: uncorrected GSTP1 BC versus GSTP1AA, P = 0.031; and corrected for age and sex, P = 0.02.