Table 2 Features of RSV infection of humans, RSV in mice, and PVM infection in mice: a comparison
From: Gene expression in epithelial cells in response to pneumovirus infection
Features | Humans infected with RSV | Mice infected with PVM | Mice infected with RSV |
|---|---|---|---|
Inoculum required | Very low (presumed) | <30 pfu | >0.5–2 million pfu |
Pulmonary inflammation | Granulocytic bronchiolitis | Granulocytic bronchiolitis | Mild mononuclear cell infiltrate |
Eosinophil recruitment | Yes | Yes (8–12%); see arrows in panel D, Fig. 1 | No |
Progression to ARDS | Yes | Yes | No |
Percent with respiratory failure | 10% | 60% (low dose); 100% (high dose) | 0% |
Weight loss | Not reported, but likely | 30% | 12–15% |
Peak lung viral titers | 106 pfu/ml nasal secretion | 106–108 pfu/g lung | Less than inoculum |