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Table 6 The effect of biological interventions in the tracheal allograft model

From: The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis

  

Dose

Treatment

Harvest

Luminal

Epithelial

Changes in

  

Animal

Compound

(mg/kg per day)

time (days)

time (days)

occlusion (%)

loss (%)

cytokines/GFs

n

Reference

Rat

Control

-

-

7

0

<25

 

5

[46]

    

21

50–75

>75

 

5

 
 

rIL-10

10 μg/ml

0–14

7

0–<25

0–<25

 

5

 
  

at 0.5 μg/h i.p.

 

21

50–75

>75

 

5

 
   

5–14

7

0

0–<25

 

5

 
    

21

<25

50–75

 

5

 

Rat

Control

-

-

7

0–<25

0–<25

 

5

[46]

    

21

50–75

>75

 

5

 
 

Adv-IL-10

i.m.

5

7

0

0–25

 

6

 
    

21

<25

50–75

 

6

 
 

Control

i.m.

5

7

0

0–<25

 

6

 
 

vector

  

21

50–75

>75

 

6

 

Rat

CsA

25 i.m

2–3

     

[31]

  

+ 5 i.m.

4–27

56

Partial

  

10

 
 

CsA

25 i.m.

2–3

      
 

+

+ 5 i.m.

4–27

      
 

IL–2

+ 90,000 IU i.p.

15–19 and 22–26

56

100

  

13

 

Rat

Control

-

 

28

>75

>75

 

5

[37]

    

42

>75

>75

 

5

 
    

56

n.a.

n.a.

 

5

 
    

70

n.a.

n.a.

 

5

 
 

CsA

25 i.m

2–3

28

0

0–<25

 

5

 
  

+ 5 i.m.

4–27

42

0–<25

<25

 

5

 
    

56

50–75

50–75

 

5

 
    

70

>75

>75

 

5

 
 

CsA

25 i.m.

2–3

28

0–<25

<25

 

5

 
 

+

+5 i.m.

4–27

42

25–50

50–75

 

5

 
 

IL-2

+300,000 IU i.p.

15–19 and 22–26

56

25–50

50–75

 

5

 
    

70

>75

50–75

 

5

 

Rat

CsA

1 s.c.

0–3

3

15

61

 

10

[60]

   

0–10

10

18

27

 

10

 
   

0–30

30

86

0

 

10

 
 

CsA

1 s.c.

0–30

3

7

18

TNF-α, IL-2,

10

 
 

+

+

+

   

PDGF-AA ↓

10

 
 

human sCR-1

20 i.p.

–1 to 7

10

8

26

 

10

 
    

30

52

0

 

10

 

Rat

Control

-

-

7

30

19

 

5

[49]

   

-

21

90

100

 

5

 
 

Control Ab

o.m.p. infusion

0–7

7

40

23

 

5

 
   

0–14

21

100

100

 

5

 
 

anti-RANTES Ab

o.m.p. infusion

0–7

7

30

4

 

5

 
  

12 μ g/day

0–14

21

35

84

 

5

 

Mouse

Control IgG

200 μg/mouse i.p.

0, 2, 4, 6

35

98

  

7

[44]

 

CTLA4 IgG

200 μg/mouse i.p.

0, 2, 4, 6

35

27

  

7

 
 

Control IgG

200 μg/mouse i.p.

6, 8, 10, 12

35

91

  

4

 
 

CTLA4 IgG

200 μg/mouse i.p.

6, 8, 10, 12

35

42

  

4

 
  1. Ab, antibody; Adv, adenovirus; CsA, cyclosporin A; GFs, growth factors; IL, interleukin; i.m., intramuscularly; i.p., intraperitoneally; n.a., not assessed; o.m.p., osmotic mini pump; PDGF, platelet-derived growth factor; rIL-10, recombinant IL-10; s.c., subcutaneously; sCR; soluble complement receptor; TNF, tumour necrosis factor.