The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis

Hele, David J; Yacoub, Magdi H; Belvisi, Maria G

doi:10.1186/rr55

Respiratory Research

Table 4 The effect of immunosuppressants in the tracheal allograft model

From: The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis

		Dose	Treatment time	Harvest time	Luminal	Epithelial
Animal	Compound	(mg/kg per day)	(days)	(days)	occlusion (%)	loss (%)	n	Reference
Rat	Control	-	0–14	14	31	100	n.r.	[19]
			0–28	28	96	100
	CsA	5 p.o.	0–14	14	10	80
			7–27	28	64	n.r.
	MPA	40 p.o.	0–14	14	18	100
	LFM	20 p.o.	0–14	14	6	12
			0–28	28	32	85
	RPM	6 i.p.	0–14	14	7	65
			0–28	28	4	100
			7–27	28	8	n.r.
	DSG	2.5 i.p.	0–28	28	20	100
			7–27	28	93	n.r.
Rat	Control	-	0–14	14	31	100	5	[20]
			0–28	28	98	100	5
	CsA	10 p.o.	0–14	14	10	80	5
			0–28	28	32	100	5
	MPA	40 p.o.	0–14	14	18	100	5
			0–28	28	63	100	5
	LFM	20 p.o.	0–14	14	7.9	100	5
			0–28	28	20	100	5
	RPM	6 i.p.	0–14	14	7.5	65	5
			0–28	28	4	100	5
	DSG	2.5 i.p.	0–14	14	5.8	11.7	5
			0–28	28	32	85	5
Rat	Control	-	0–13	14	31		5	[18]
	CsA	5 p.o.	0–13	14	0		5
	MPA	40 p.o.	0–13	14	0		5
	LFM	20 p.o.	0–13	14	0		5
	RPM	6 i.p.	0–13	14	0		5
Mouse	Control	-	0–30	30	89	100	10	[38]
	CsA	5 i.p.	0–30	30	n.e.	n.e.	7
		10 i.p.	0–30	30	n.e.	n.e.	7
		15 i.p.	0–30	30	n.e.	n.e.	7
		25 i.p.	0–30	30	–19	n.e.	7
Mouse	Control	-		28	40–90	100	5	[39]
	RPM	9 i.p.	1–28	28	0 to <–5	0	5
		12 i.p.	14–28	28	0 to <–5	0	5
Rat	Control	-	0–30	30	100	100	6	[26]
	CsA	1 s.c.	0–30	30	100	25	4
		2 s.c.	0–30	30	0	0	4
		5 s.c.	0–30	30	0	0	6
	DSG	1 i.p.	0–30	30	100	100	6
	MPM	2 i.p.	0–30	30	50	50	4
		20 i.p.	0–30	30	100	100	6
		40 i.p.^*	0–30	30	100	100	4
Rat	Control	-	0–28	28	100		n.r.	[32]
	CsA	5	0–28	28	0
	RPM	6	0–28	28	0
	DSG	2.5	0–28	28	100
	LFM	20	0–28	28	5
	MPA	40	0–28	28	30
Rat	Control	-	0–27	28	100	100	All 5–10	[34]
			0–50	28	100	100
	CsA	10 p.o.	0–27	28	4	0
			7–27	28	14–100	56
			0–49	50	22	0
	MPM	40 p.o.	0–27	28	47	Partial
			7–27	28	93	100
	LFM	20 p.o.	0–27	28	11	Partial
			7–27	28	62	100
			0–49	50	21	19
	RPM	6 i.p.	0–27	28	6	36
			7–27	28	16	100
			14–27	28	72	100
			0–49	50	16	29
	DSG	2.5 i.p.	0–27	28	42	80
			7–27	28	98	100
Rat	Control	-	0–3	28	~100		6	[36]
	FK506	0.5 i.m.	0–3	28	~100		8
		1 i.m.	0–3	28	~100		8
		1.5 i.m.	0–3	28	~30		8

^*Toxic at this dose; CsA, cyclosporin A; DSG, deoxyspergualin; i.m., intramuscularly; i.p., intraperitoneally; MPA, mycophenolic acid; MPM, mycophenolate mofetil; n.e., no effect; n.r., not reported; p.o., orally; RPM, rapamycin; s.c., subcutaneously.

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